HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: NCOA2 (Q15596)
Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)
Gene: NCOA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 11937504, 18499756, 14766010, 17697320, 20348541, 26487511, 19460354, 12612084, 16645043, 12714702, 15657427, 9192892, 12630920, 12554772, 11376110, 11014206, 9774463, 9430642, 11265755
Identification Methods pull down, affinity chromatography technology, two hybrid, x-ray crystallography, fluorescent resonance energy transfer, unspecified method, biochemical
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 595
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025