HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26402096
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 1374
+	Hs
		529136 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK3_HUMAN (622-1374): 2.86e-159: 499: 15.62
+	Hs
		530003 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK2_HUMAN (629-1374): 3.24e-149: 473: 13.53
+	Hs
		530482 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK1_HUMAN (622-1374): 8.4e-144: 459: 14.77
+	Hs
		270762 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ROCK2_HUMAN (668-1343): 8.19e-114: 392: 17.55
+	Hs
		529382 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KS6A3_HUMAN (613-1163): 5.59e-119: 391: 17.99
+	Hs
		529850 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KS6A1_HUMAN (628-1163): 4.88e-114: 377: 17.63
+	Hs
		287650 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KS6A5_HUMAN (673-1032): 2.5e-109: 366: 23.20
+	Hs
		96829 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		E9PBG7_HUMAN (678-1086): 6.89e-113: 366: 22.73
+	Hs
		536317 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK3_HUMAN (622-1374): 2.86e-159: 499: 15.62
+	Hs
		529730 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		PAK2_HUMAN (686-960): 1.35e-97: 325: 31.27
+	Hs
		529756 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KCC2D_HUMAN (678-995): 1.23e-97: 324: 26.53
+	Mm
		530893 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		KCC2G_MOUSE (678-1086): 3.01e-112: 365: 22.80
+	Hs
		551607 NFH_HUMAN (113-708): 1.12e-25: 115: 10.96		NEK4_HUMAN (680-1303): 3.24e-113: 378: 19.70
+	Hs
		908996 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		NEK4_HUMAN (680-1303): 3.24e-113: 378: 19.70
+	Hs
		1129782 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		KS6A6_HUMAN (673-1074): 2.16e-113: 376: 21.31
+	Hs
		170137 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		AURKA_HUMAN (551-947): 1.46e-115: 369: 22.36
+	Mm
		631789 MTAP2_MOUSE (26-758): 2.26e-30: 131: 24.41		KCC2D_MOUSE (678-995): 1.23e-97: 324: 26.53
+	Hs
		698243 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		NEK4_HUMAN (680-1303): 3.24e-113: 378: 19.70
+	Hs
		529186 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT2_HUMAN (438-621): 6.37e-26: 115: 13.30
+	Hs
		529185 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT1_HUMAN (469-615): 2.82e-13: 76: 11.92