HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: OLIG1 (Q8TAK6)
Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21)
Gene: OLIG1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15280210
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070888 - E-box binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 271
+	Hs
		551521 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF1_HUMAN (95-263): 5.01e-35: 130: 28.07
+	Hs
		526739 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF5_HUMAN (69-264): 1.29e-33: 124: 14.83
+	Hs
		551520 TFE2_HUMAN (1-654): 0: 907: 100.00		OLIG2_HUMAN (41-254): 4.45e-32: 122: 32.39
+	Hs
		551577 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF4_HUMAN (95-261): 4.66e-32: 122: 28.27
+	Hs
		546066 TFE2_HUMAN (1-654): 0: 907: 100.00		MYOG_HUMAN (32-236): 3.01e-30: 114: 16.67
+	Hs
		551544 TFE2_HUMAN (1-654): 0: 907: 100.00		PTF1A_HUMAN (49-243): 1.33e-28: 112: 22.96
+	Hs
		551565 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN1_HUMAN (34-240): 1.7e-27: 107: 23.19
+	Hs
		551594 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN3_HUMAN (40-228): 1.5e-27: 107: 22.55
+	Hs
		551464 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL1_HUMAN (17-254): 3.52e-26: 106: 18.33
+	Hs
		551472 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF6_HUMAN (22-206): 9.62e-26: 103: 18.62
+	Hs
		551564 TFE2_HUMAN (1-654): 0: 907: 100.00		ATOH1_HUMAN (87-241): 4.34e-24: 101: 22.98
+	Hs
		551490 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND2_HUMAN (45-176): 8.39e-25: 100: 25.93
+	Hs
		551533 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL2_HUMAN (105-218): 5.95e-26: 100: 28.95
+	Hs
		551559 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST2_HUMAN (56-173): 2.61e-25: 100: 32.77
+	Hs
		551569 TFE2_HUMAN (1-654): 0: 907: 100.00		FER3L_HUMAN (94-177): 1.25e-24: 98.2: 32.14
+	Hs
		210857 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF21_HUMAN (69-198): 2.46e-24: 97.8: 25.36
+	Hs
		551543 TFE2_HUMAN (1-654): 0: 907: 100.00		BHA15_HUMAN (40-220): 1.11e-20: 88.5: 24.47
+	Mm
		550180 TFE2_MOUSE (1-654): 0: 861: 82.50		TAL1_MOUSE (21-254): 2.09e-26: 107: 20.09
+	Mm
		192773 TFE2_MOUSE (1-654): 0: 861: 82.50		TCF21_MOUSE (69-198): 2.28e-25: 100: 25.36
+	Mm
		550186 TFE2_MOUSE (1-654): 0: 861: 82.50		ATOH1_MOUSE (87-170): 1.2e-13: 71.9: 35.71