HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12861019
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 180
+	Hs
		476198 UBC_HUMAN (1-685): 0: 846: 100.00		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		475680 UBC_HUMAN (1-685): 0: 846: 100.00		TRI26_HUMAN (14-123): 1.73e-28: 112: 21.85
+	Hs
		476418 UBC_HUMAN (1-685): 0: 846: 100.00		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (23-148): 9.12e-25: 101: 18.11
+	Hs
		475759 UBC_HUMAN (1-685): 0: 846: 100.00		HLTF_HUMAN (20-77): 5.99e-21: 90.9: 29.31
+	Hs
		476560 UBC_HUMAN (1-685): 0: 846: 100.00		CBLC_HUMAN (6-93): 1.05e-19: 87.1: 28.28
+	Hs
		475431 UBC_HUMAN (1-685): 0: 846: 100.00		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62
+	Xl
		1140135 Q7SY79_XENLA (77-685): 0: 744: 99.84		Q5XGX4_XENLA (2-179): 3.83e-56: 176: 56.74
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (4-152): 3.85e-27: 108: 16.45
+	Dm
		1215068 Q9W418_DROME (229-685): 0: 557: 99.78		Q8IR26_DROME (3-179): 2.28e-52: 170: 48.32
+	Dm
		1375478 R9PY16_DROME (457-685): 5.07e-80: 258: 90.39		Q9VXP1_DROME (3-178): 1.17e-57: 183: 47.73
+	Dm
		1215070 R9PY16_DROME (457-685): 5.07e-80: 258: 90.39		Q8IR26_DROME (3-179): 2.28e-52: 170: 48.32
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (10-156): 5.16e-24: 99.4: 13.51
+	At
		1092004 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		SM3L1_ARATH (20-77): 2.3e-18: 83.7: 24.14
+	Xl
		1140130 Q6GMC1_XENLA (609-684): 7.23e-41: 148: 100.00		Q5XGX4_XENLA (2-179): 3.83e-56: 176: 56.74
+	Hs
		924117 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		924151 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (10-156): 5.16e-24: 99.4: 13.51
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (10-156): 5.16e-24: 99.4: 13.51
+	Mm
		476705 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		BRCA1_MOUSE (25-76): 9.49e-19: 84.8: 34.62