HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: FER3L (Q96RJ6)
Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist)
Gene: FERD3L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 166
+	Hs
		551462 TFE2_HUMAN (1-654): 0: 907: 100.00		TFE2_HUMAN (2-166): 1.28e-29: 115: 18.71
+	Hs
		526739 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF5_HUMAN (29-163): 1.45e-28: 107: 25.53
+	Hs
		551056 TFE2_HUMAN (1-654): 0: 907: 100.00		ITF2_HUMAN (1-164): 8.46e-27: 107: 17.13
+	Hs
		551472 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF6_HUMAN (16-164): 2.17e-28: 106: 22.82
+	Hs
		545932 TFE2_HUMAN (1-654): 0: 907: 100.00		MYOD1_HUMAN (8-161): 2.65e-27: 105: 25.33
+	Hs
		551515 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF15_HUMAN (52-166): 1.09e-27: 104: 33.61
+	Hs
		551521 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF1_HUMAN (92-164): 1.43e-26: 104: 42.47
+	Hs
		551564 TFE2_HUMAN (1-654): 0: 907: 100.00		ATOH1_HUMAN (4-164): 2.99e-26: 103: 25.99
+	Hs
		551565 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN1_HUMAN (42-166): 2.15e-26: 101: 32.00
+	Hs
		551578 TFE2_HUMAN (1-654): 0: 907: 100.00		ASCL3_HUMAN (18-163): 4.26e-27: 101: 24.32
+	Hs
		210857 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF21_HUMAN (58-166): 1.67e-26: 100: 29.46
+	Hs
		551490 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND2_HUMAN (17-163): 4.6e-26: 100: 20.41
+	Hs
		551577 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF4_HUMAN (92-165): 3.26e-25: 100: 44.60
+	Hs
		551544 TFE2_HUMAN (1-654): 0: 907: 100.00		PTF1A_HUMAN (44-160): 1.51e-24: 98.8: 31.62
+	Hs
		551533 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL2_HUMAN (100-166): 3.02e-26: 97.5: 40.30
+	Hs
		551594 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN3_HUMAN (81-158): 8.12e-25: 97.1: 44.87
+	Hs
		551559 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST2_HUMAN (44-161): 1.07e-24: 95.2: 31.36
+	Hs
		551530 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST1_HUMAN (57-162): 2.8e-23: 92.5: 34.91
+	Hs
		551547 TFE2_HUMAN (1-654): 0: 907: 100.00		SCX_HUMAN (54-161): 1.17e-22: 90.9: 29.83
+	Rn
		600265 TFE2_RAT (1-654): 0: 879: 81.83		Q9EPJ1_RAT (93-162): 1.02e-22: 91.3: 42.86