HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: K1C25 (Q7Z3Z0)
Keratin, type I cytoskeletal 25 (Cytokeratin-25) (CK-25) (Keratin-25) (K25) (Keratin-25A) (K25A) (Type I inner root sheath-specific keratin-K25irs1)
Gene: KRT25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 450
+	Hs
		437183 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1H1_HUMAN (72-421): 1.26e-146: 425: 44.29
+	Hs
		385035 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C14_HUMAN (77-447): 9.16e-145: 423: 53.64
+	Hs
		437152 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C17_HUMAN (72-441): 3.92e-144: 420: 52.70
+	Hs
		437075 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C10_HUMAN (74-383): 3.37e-128: 384: 69.03
+	Hs
		437196 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C24_HUMAN (74-429): 9.83e-127: 379: 60.22
+	Hs
		437064 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C16_HUMAN (75-409): 9.48e-118: 354: 59.40
+	Hs
		437076 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C13_HUMAN (67-392): 5.09e-113: 341: 57.06
+	Hs
		437088 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C15_HUMAN (78-392): 1.41e-112: 340: 59.37
+	Hs
		49878 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		A1A4E9_HUMAN (67-392): 1.26e-112: 340: 56.75
+	Hs
		437062 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C19_HUMAN (73-391): 1.71e-110: 333: 56.43
+	Hs
		227198 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		KRT86_HUMAN (5-394): 2.41e-96: 299: 22.00
+	Hs
		341724 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C75_HUMAN (2-406): 3.89e-92: 290: 23.65
+	Hs
		437171 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		KT33B_HUMAN (73-416): 1.94e-88: 276: 45.06
+	Hs
		437176 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C72_HUMAN (2-397): 4.37e-86: 274: 21.41
+	Hs
		437172 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1H2_HUMAN (6-401): 3.92e-82: 262: 40.66
+	Hs
		300545 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		KRT36_HUMAN (7-442): 9.19e-81: 258: 42.20
+	Hs
		407237 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C6B_HUMAN (44-413): 2.05e-79: 258: 20.76
+	Hs
		437077 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C5_HUMAN (44-397): 2.81e-79: 258: 22.54
+	Hs
		437121 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C6C_HUMAN (44-413): 1.59e-79: 258: 21.02
+	Hs
		385216 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C6A_HUMAN (44-413): 5.91e-78: 254: 21.02