HitPredict

Interactor 1: FCG2A (P12318)
Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
Gene: FCGR2A

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	9268059, 11141335, 15136586, 7487883
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0032760 - positive regulation of tumor necrosis factor production
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 635
+	Hs
		553423 FCERA_HUMAN (20-247): 2.23e-60: 195: 32.02		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		473498 FCG3A_HUMAN (16-255): 7.02e-50: 168: 43.03		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		629546 CD22_HUMAN (31-274): 3.12e-30: 122: 15.89		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		849229 FCRL3_HUMAN (22-311): 6.89e-28: 115: 17.65		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		553344 FCGR1_HUMAN (39-278): 1.7e-26: 109: 17.06		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		849079 FCRL3_HUMAN (22-311): 6.89e-28: 115: 17.65		ZAP70_HUMAN (6-635): 0: 531: 53.41
+	Hs
		710503 ROBO2_HUMAN (1-314): 5.76e-39: 148: 14.61		EPHA2_HUMAN (175-631): 4.48e-115: 368: 25.81
+	Hs
		710428 KIRR1_HUMAN (29-220): 2.55e-29: 119: 19.90		EPHA2_HUMAN (175-631): 4.48e-115: 368: 25.81
+	Hs
		557130 FCG2C_HUMAN (1-317): 6.88e-78: 242: 85.17		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		440404 FCG2C_HUMAN (1-317): 6.88e-78: 242: 85.17		FYN_HUMAN (5-371): 1.27e-71: 242: 14.90
+	Hs
		553417 FCERA_HUMAN (20-247): 2.23e-60: 195: 32.02		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		439913 FCG3A_HUMAN (16-255): 7.02e-50: 168: 43.03		LCK_HUMAN (5-201): 5.99e-74: 247: 23.29
+	Hs
		557532 TUTLB_HUMAN (3-316): 4.24e-43: 160: 14.50		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		463262 TUTLB_HUMAN (3-316): 4.24e-43: 160: 14.50		YES_HUMAN (5-203): 1.55e-70: 239: 21.17
+	Dm
		233626 O44924_DROME (3-317): 3.87e-37: 143: 12.36		ABL_DROME (4-376): 9.5e-58: 213: 13.97
+	Hs
		840903 TUTLB_HUMAN (3-316): 4.24e-43: 160: 14.50		TEC_HUMAN (6-379): 4.77e-49: 183: 13.37
+	Hs
		363714 KIRR1_HUMAN (29-220): 2.55e-29: 119: 19.90		EGFR_HUMAN (375-619): 8.77e-57: 209: 43.15
+	Hs
		411001 KIRR1_HUMAN (29-220): 2.55e-29: 119: 19.90		ERBB2_HUMAN (375-619): 1.48e-52: 197: 42.34
+	Mm
		465768 FCGR1_MOUSE (30-311): 1.08e-27: 112: 18.27		HCK_MOUSE (15-176): 1.45e-38: 151: 23.37
+	Hs
		473360 FCGR1_HUMAN (39-278): 1.7e-26: 109: 17.06		HCK_HUMAN (104-310): 5.69e-24: 108: 21.03