HitPredict

Interactor 1: FCERA (P12319)
High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)
Gene: FCER1A

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9103201
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043303 - mast cell degranulation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 257 Hs			1 635
+	Hs
		553389 FCG2A_HUMAN (19-204): 1.79e-44: 154: 35.48		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		473498 FCG3A_HUMAN (18-226): 1.28e-44: 152: 37.32		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		629546 CD22_HUMAN (24-244): 2.87e-27: 112: 18.03		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		553344 FCGR1_HUMAN (2-236): 4.58e-22: 95.6: 19.68		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		849229 FCRL3_HUMAN (30-241): 8.35e-21: 93.3: 17.83		KSYK_HUMAN (1-635): 0: 587: 100.00
+	Hs
		849079 FCRL3_HUMAN (30-241): 8.35e-21: 93.3: 17.83		ZAP70_HUMAN (6-635): 0: 531: 53.41
+	Hs
		710600 ROBO1_HUMAN (5-221): 7.47e-35: 134: 16.09		EPHA2_HUMAN (175-631): 4.48e-115: 368: 25.81
+	Hs
		710503 ROBO2_HUMAN (6-196): 4.1e-32: 126: 18.75		EPHA2_HUMAN (175-631): 4.48e-115: 368: 25.81
+	Hs
		553417 FCERA_HUMAN (1-257): 4.41e-72: 223: 100.00		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		557129 FCG2B_HUMAN (10-247): 7.1e-48: 162: 33.89		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		557130 FCG2C_HUMAN (10-210): 2.18e-47: 161: 36.14		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		440403 FCG2B_HUMAN (10-247): 7.1e-48: 162: 33.89		FYN_HUMAN (5-371): 1.27e-71: 242: 14.90
+	Hs
		440404 FCG2C_HUMAN (10-210): 2.18e-47: 161: 36.14		FYN_HUMAN (5-371): 1.27e-71: 242: 14.90
+	Hs
		439913 FCG3A_HUMAN (18-226): 1.28e-44: 152: 37.32		LCK_HUMAN (5-201): 5.99e-74: 247: 23.29
+	Dm
		233626 O44924_DROME (1-210): 1.23e-33: 130: 17.65		ABL_DROME (4-376): 9.5e-58: 213: 13.97
+	Dm
		362461 LAR_DROME (30-219): 4.01e-31: 123: 19.14		ABL_DROME (4-376): 9.5e-58: 213: 13.97
+	Hs
		557532 TUTLB_HUMAN (116-248): 5.52e-13: 70.5: 11.80		SRC_HUMAN (5-371): 3.24e-72: 244: 15.52
+	Hs
		463262 TUTLB_HUMAN (116-248): 5.52e-13: 70.5: 11.80		YES_HUMAN (5-203): 1.55e-70: 239: 21.17
+	Mm
		465768 FCGR1_MOUSE (6-224): 4.19e-21: 93.2: 19.40		HCK_MOUSE (15-176): 1.45e-38: 151: 23.37
+	Hs
		473360 FCGR1_HUMAN (2-236): 4.58e-22: 95.6: 19.68		HCK_HUMAN (104-310): 5.69e-24: 108: 21.03