HitPredict

Interactor 1: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Interactor 2: PTPRS (Q13332)
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Gene: PTPRS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21126580
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030517 - negative regulation of axon extension GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 882 Hs			1 1948
+	Hs
		522579 CADH1_HUMAN (1-882): 0: 829: 100.00		PTPRF_HUMAN (1-1948): 0: 1534: 65.68
+	Hs
		522743 PCDBG_HUMAN (376-868): 2.64e-72: 255: 16.96		PTPRF_HUMAN (1-1948): 0: 1534: 65.68
+	Rn
		1225811 CADH2_RAT (4-365): 1.58e-34: 144: 13.98		PTPRF_RAT (1-1948): 0: 1543: 65.57
+	Hs
		555876 CADH1_HUMAN (1-882): 0: 829: 100.00		PTPRG_HUMAN (843-1945): 0: 789: 26.42
+	Hs
		555875 CADH1_HUMAN (1-882): 0: 829: 100.00		PTPRD_HUMAN (4-1068): 1.21e-104: 375: 19.18
+	Hs
		556048 CADH1_HUMAN (1-882): 0: 829: 100.00		PTPRJ_HUMAN (1651-1945): 1.57e-106: 375: 37.29
+	Hs
		658884 DSC3_HUMAN (2-874): 0: 655: 27.92		PTPRD_HUMAN (4-1068): 1.21e-104: 375: 19.18
+	Mm
		486802 CADH1_MOUSE (1-882): 0: 793: 81.45		PTPRQ_MOUSE (885-1445): 8.11e-24: 112: 12.52
+	Hs
		555891 CADH1_HUMAN (1-882): 0: 829: 100.00		PTPRM_HUMAN (33-462): 1.15e-12: 75.8: 12.91
+	Mm
		486811 CADH1_MOUSE (1-882): 0: 793: 81.45		PTPRM_MOUSE (33-462): 1.93e-11: 72: 12.69
+	Hs
		658936 PCDBG_HUMAN (376-868): 2.64e-72: 255: 16.96		PTPRD_HUMAN (4-1068): 1.21e-104: 375: 19.18
+	Hs
		658946 PCDB6_HUMAN (382-868): 2.33e-66: 239: 15.85		PTPRD_HUMAN (4-1068): 1.21e-104: 375: 19.18
+	Hs
		658809 CADH5_HUMAN (30-511): 1.86e-51: 195: 20.55		PTPRB_HUMAN (270-1309): 7.01e-38: 159: 13.33
+	Mm
		74089 CADH5_MOUSE (30-511): 4.84e-49: 188: 21.06		PTPRB_MOUSE (262-1309): 3.6e-38: 159: 12.03
+	Hs
		1366855 PCDB3_HUMAN (415-868): 2.15e-66: 239: 15.11		PTPRU_HUMAN (211-781): 1.34e-19: 98.5: 13.55
+	Hs
		1366854 PCDB7_HUMAN (385-867): 7.2e-66: 237: 15.45		PTPRU_HUMAN (211-781): 1.34e-19: 98.5: 13.55
+	Mm
		504798 CADH5_MOUSE (30-511): 4.84e-49: 188: 21.06		PTPRQ_MOUSE (885-1445): 8.11e-24: 112: 12.52
+	Hs
		749797 CADH5_HUMAN (30-511): 1.86e-51: 195: 20.55		PTPRU_HUMAN (211-781): 1.34e-19: 98.5: 13.55
+	Mm
		504795 CADH2_MOUSE (4-365): 2.3e-35: 147: 14.25		PTPRQ_MOUSE (885-1445): 8.11e-24: 112: 12.52
+	Rn
		98591 CADH2_RAT (4-365): 1.58e-34: 144: 13.98		F1LPJ1_RAT (33-462): 1.53e-11: 72: 12.69