HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.947

The method score is based on:

Property Details
Experiments 8657134, 21573184, 15313931, 12244095, 19372587, 18070987
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~STAT_linker, SH2~SH3_1
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005102 - signaling receptor binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005743 - mitochondrial inner membrane
and 7 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 536
Hs

1 770
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Service provided by Combinatics, Japan

Last updated: 11Aug2025