HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: PDGFC (Q9NRA1)
Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]
Gene: PDGFC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.705

The method score is based on:

Property Details
Experiments 11297552, 35384245, 20534510, 10806482
Identification Methods pull down, affinity chromatography technology, cross-linking study, isothermal titration calorimetry, competition binding
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005161 - platelet-derived growth factor receptor binding
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0008284 - positive regulation of cell population proliferation
GO:0030335 - positive regulation of cell migration
and 5 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1089
Hs

1 345
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Last updated: 15 Jul 2024