HitPredict

Interactor 1: K1C10 (P13645)
Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)
Gene: KRT10

Interactor 2: KRT84 (Q9NSB2)
Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)
Gene: KRT84

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0030280 - structural constituent of skin epidermis GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 584 Hs			1 600
+	Hs
		475754 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C7_HUMAN (92-487): 1.26e-146: 433: 62.56
+	Hs
		475738 K1C10_HUMAN (141-454): 1.7e-147: 439: 100.00		K2C7_HUMAN (92-487): 1.26e-146: 433: 62.56
+	Hs
		1047491 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		KRT84_HUMAN (1-600): 6.01e-132: 400: 100.00
+	Hs
		437152 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C8_HUMAN (83-508): 1.98e-110: 341: 55.63
+	Hs
		437075 K1C10_HUMAN (141-454): 1.7e-147: 439: 100.00		K2C8_HUMAN (83-508): 1.98e-110: 341: 55.63
+	Hs
		227197 K1C14_HUMAN (144-457): 2.58e-144: 427: 69.43		KRT86_HUMAN (56-536): 1.51e-89: 287: 59.46
+	Hs
		341758 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C75_HUMAN (1-479): 7.03e-82: 269: 50.82
+	Hs
		341731 K1C10_HUMAN (141-454): 1.7e-147: 439: 100.00		K2C75_HUMAN (1-479): 7.03e-82: 269: 50.82
+	Hs
		566362 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C5_HUMAN (1-479): 3.8e-75: 252: 51.32
+	Hs
		566093 K1C10_HUMAN (141-454): 1.7e-147: 439: 100.00		K2C5_HUMAN (1-479): 3.8e-75: 252: 51.32
+	Hs
		1047431 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C79_HUMAN (24-552): 4.6e-75: 250: 45.32
+	Hs
		407275 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C6B_HUMAN (1-479): 3.79e-73: 246: 52.98
+	Hs
		407245 K1C10_HUMAN (141-454): 1.7e-147: 439: 100.00		K2C6B_HUMAN (1-479): 3.79e-73: 246: 52.98
+	Hs
		876459 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C6C_HUMAN (1-479): 8.82e-73: 245: 53.18
+	Hs
		1047416 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C72_HUMAN (78-479): 1.05e-71: 241: 54.21
+	Hs
		385261 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K2C6A_HUMAN (1-479): 1.04e-70: 239: 52.98
+	Hs
		385229 K1C10_HUMAN (141-454): 1.7e-147: 439: 100.00		K2C6A_HUMAN (1-479): 1.04e-70: 239: 52.98
+	Hs
		1030977 K1C17_HUMAN (140-456): 6.24e-150: 440: 70.03		K22O_HUMAN (1-482): 5.4e-65: 226: 48.81
+	Hs
		566136 K1C10_HUMAN (141-454): 1.7e-147: 439: 100.00		K22O_HUMAN (1-482): 5.4e-65: 226: 48.81
+	Mm
		1424270 K1C27_MOUSE (140-470): 5.1e-146: 430: 65.96		K2C7_MOUSE (86-477): 1.41e-63: 218: 57.76