HitPredict

Interactor 1: K22O (Q01546)
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)
Gene: KRT76

Interactor 2: K1C17 (Q04695)
Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17)
Gene: KRT17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0031424 - keratinization GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 432
+	Hs
		437064 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C16_HUMAN (80-410): 1.71e-159: 460: 79.28
+	Hs
		385035 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C14_HUMAN (82-430): 3.38e-151: 438: 82.40
+	Hs
		437062 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C19_HUMAN (77-394): 1.39e-146: 424: 73.59
+	Hs
		437076 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C13_HUMAN (73-398): 8.51e-143: 417: 70.73
+	Hs
		49878 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		A1A4E9_HUMAN (73-398): 2.56e-142: 416: 70.43
+	Hs
		437088 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C15_HUMAN (83-426): 6.22e-141: 412: 68.66
+	Hs
		437075 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C10_HUMAN (79-389): 1.16e-123: 372: 69.75
+	Hs
		300282 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT34_HUMAN (77-395): 9.2e-117: 348: 58.62
+	Hs
		437109 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C20_HUMAN (69-423): 4.4e-116: 347: 55.40
+	Hs
		437152 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1C17_HUMAN (1-432): 2.41e-111: 335: 100.00
+	Hs
		341724 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C75_HUMAN (10-408): 3.96e-83: 267: 26.19
+	Hs
		300718 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT38_HUMAN (1-395): 8.87e-80: 255: 44.75
+	Hs
		300620 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT37_HUMAN (1-395): 2.05e-79: 254: 44.00
+	Hs
		300259 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KT33A_HUMAN (34-405): 4.67e-78: 249: 52.69
+	Hs
		300545 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT36_HUMAN (2-395): 3.77e-77: 248: 55.47
+	Hs
		407237 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C6B_HUMAN (50-414): 7.91e-71: 235: 23.43
+	Hs
		437077 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C5_HUMAN (50-398): 9.61e-71: 235: 25.07
+	Hs
		437121 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C6C_HUMAN (50-414): 1.69e-70: 234: 23.43
+	Hs
		385216 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C6A_HUMAN (50-414): 1.1e-69: 232: 23.71
+	Hs
		227198 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT86_HUMAN (7-430): 6.47e-11: 66: 11.98