HitPredict

Interactor 1: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Interactor 2: K1H1 (Q15323)
Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1) (Keratin-31) (K31)
Gene: KRT31

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0008544 - epidermis development GO:0045109 - intermediate filament organization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 416
+	Hs
		300622 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT37_HUMAN (17-409): 1.92e-148: 430: 60.91
+	Hs
		551565 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C40_HUMAN (6-385): 2.33e-143: 416: 62.69
+	Hs
		385045 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C14_HUMAN (54-367): 6.74e-142: 414: 61.15
+	Hs
		475506 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C19_HUMAN (48-366): 8.95e-141: 409: 56.11
+	Hs
		551566 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C39_HUMAN (36-416): 1.52e-133: 394: 62.30
+	Hs
		476258 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C16_HUMAN (54-382): 2.64e-115: 347: 58.36
+	Hs
		551535 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C15_HUMAN (55-367): 1.79e-111: 336: 57.96
+	Hs
		551531 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C13_HUMAN (50-373): 2.1e-108: 328: 56.00
+	Hs
		551586 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C12_HUMAN (50-363): 1.86e-103: 317: 54.40
+	Hs
		341729 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C75_HUMAN (19-381): 5.07e-95: 297: 26.58
+	Hs
		300291 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT34_HUMAN (1-391): 2.98e-95: 292: 89.00
+	Hs
		551539 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1C20_HUMAN (52-364): 9.94e-95: 292: 50.48
+	Hs
		300721 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT38_HUMAN (11-413): 1.22e-92: 288: 60.89
+	Hs
		551557 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1H1_HUMAN (1-416): 2.67e-90: 280: 100.00
+	Hs
		551555 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1H2_HUMAN (5-406): 1.12e-87: 275: 69.15
+	Hs
		551578 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT35_HUMAN (2-412): 4.84e-87: 273: 69.83
+	Hs
		551532 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C5_HUMAN (19-370): 7.66e-84: 269: 25.71
+	Hs
		385226 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C6A_HUMAN (19-391): 4.52e-83: 266: 24.27
+	Hs
		300547 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT36_HUMAN (4-400): 1.13e-81: 260: 69.65
+	Hs
		551554 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KT33B_HUMAN (1-414): 1.1e-82: 260: 91.55