HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: WDFY4 (Q6ZS81)
WD repeat- and FYVE domain-containing protein 4
Gene: WDFY4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 3184
+	Hs
		385193 NTRK1_HUMAN (1-796): 0: 621: 100.00		NBEA_HUMAN (1063-1782): 2.86e-145: 512: 14.40
+	Hs
		384506 NTRK1_HUMAN (1-796): 0: 621: 100.00		LRBA_HUMAN (1063-1718): 8.79e-143: 504: 13.26
+	Hs
		508110 FGFR1_HUMAN (195-794): 0: 545: 26.34		NBEA_HUMAN (1063-1782): 2.86e-145: 512: 14.40
+	Hs
		507915 FGFR1_HUMAN (195-794): 0: 545: 26.34		LRBA_HUMAN (1063-1718): 8.79e-143: 504: 13.26
+	Hs
		1081538 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		NBEA_HUMAN (1063-1782): 2.86e-145: 512: 14.40
+	Hs
		841980 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		LRBA_HUMAN (1063-1718): 8.79e-143: 504: 13.26
+	Hs
		841979 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		LRBA_HUMAN (1063-1718): 8.79e-143: 504: 13.26
+	Hs
		608051 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		NBEA_HUMAN (1063-1782): 2.86e-145: 512: 14.40
+	Hs
		607923 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		LRBA_HUMAN (1063-1718): 8.79e-143: 504: 13.26
+	Hs
		841961 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		LRBA_HUMAN (1063-1718): 8.79e-143: 504: 13.26
+	Hs
		384596 NTRK1_HUMAN (1-796): 0: 621: 100.00		WDR5_HUMAN (2963-3181): 1.3e-65: 229: 21.40
+	Hs
		384626 NTRK1_HUMAN (1-796): 0: 621: 100.00		RACK1_HUMAN (2838-3153): 1e-49: 182: 14.15
+	Hs
		1244931 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		NBEA_HUMAN (1063-1782): 2.86e-145: 512: 14.40
+	Hs
		842042 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		LRBA_HUMAN (1063-1718): 8.79e-143: 504: 13.26
+	Hs
		384954 NTRK1_HUMAN (1-796): 0: 621: 100.00		WDR81_HUMAN (2975-3180): 5.83e-16: 87.6: 16.67
+	Hs
		384438 NTRK1_HUMAN (1-796): 0: 621: 100.00		LIS1_HUMAN (3115-3184): 4.36e-16: 85.7: 11.54
+	Hs
		609202 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		LIS1_HUMAN (3115-3184): 4.36e-16: 85.7: 11.54
+	Hs
		435605 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		RACK1_HUMAN (2838-3153): 1e-49: 182: 14.15
+	Hs
		411353 INSR_HUMAN (493-777): 3e-68: 248: 42.62		RACK1_HUMAN (2838-3153): 1e-49: 182: 14.15
+	Hs
		929718 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		RACK1_HUMAN (2838-3153): 1e-49: 182: 14.15