HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	20479273, 22659184
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 439 Hs			1 491
+	Hs
		906813 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		906992 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		874832 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		MDM2_HUMAN (1-491): 0: 710: 100.00