HitPredict

Interactor 1: ID3 (P41133)
DNA-binding protein inhibitor ID-3 (ID-like protein inhibitor HLH 462) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Interactor 2: HTF4 (Q61286)
Transcription factor 12 (TCF-12) (Class A helix-loop-helix transcription factor ME1) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
Gene: Tcf12

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	8759016
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression GO:0043425 - bHLH transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 119 Mm			1 706
+	Hs
		1037115 ID3_HUMAN (1-119): 9.89e-65: 193: 96.64		HTF4_HUMAN (1-706): 0: 891: 92.21
+	Mm
		832351 ID2_MOUSE (1-118): 4.52e-42: 136: 39.13		HTF4_MOUSE (1-706): 0: 925: 100.00
+	Hs
		832326 ID1_HUMAN (1-100): 2.58e-43: 140: 47.22		HTF4_HUMAN (1-706): 0: 891: 92.21
+	Hs
		1036544 ID2_HUMAN (1-118): 1.5e-42: 137: 39.86		HTF4_HUMAN (1-706): 0: 891: 92.21
+	Mm
		832287 ID3_MOUSE (1-119): 2.87e-63: 189: 100.00		ITF2_MOUSE (2-706): 0: 781: 59.55
+	Hs
		587054 ID3_HUMAN (1-119): 9.89e-65: 193: 96.64		ITF2_HUMAN (2-706): 0: 754: 59.05
+	Hs
		587449 ID3_HUMAN (1-119): 9.89e-65: 193: 96.64		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Mm
		832350 ID2_MOUSE (1-118): 4.52e-42: 136: 39.13		ITF2_MOUSE (2-706): 0: 781: 59.55
+	Rn
		639856 ID3_RAT (1-119): 2.57e-63: 189: 99.16		TFE2_RAT (1-706): 0: 726: 46.60
+	Mm
		586084 ID3_MOUSE (1-119): 2.87e-63: 189: 100.00		TFE2_MOUSE (1-706): 0: 706: 46.89
+	Hs
		587019 ID1_HUMAN (1-100): 2.58e-43: 140: 47.22		ITF2_HUMAN (2-706): 0: 754: 59.05
+	Hs
		587053 ID2_HUMAN (1-118): 1.5e-42: 137: 39.86		ITF2_HUMAN (2-706): 0: 754: 59.05
+	Hs
		587424 ID1_HUMAN (1-100): 2.58e-43: 140: 47.22		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Hs
		587448 ID2_HUMAN (1-118): 1.5e-42: 137: 39.86		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Mm
		586085 ID2_MOUSE (1-118): 4.52e-42: 136: 39.13		TFE2_MOUSE (1-706): 0: 706: 46.89
+	Mm
		586079 ID1_MOUSE (3-100): 7.66e-41: 134: 46.60		TFE2_MOUSE (1-706): 0: 706: 46.89
+	Mm
		832290 ID3_MOUSE (1-119): 2.87e-63: 189: 100.00		Q91XK1_MOUSE (193-706): 0: 579: 61.03
+	Mm
		832353 ID2_MOUSE (1-118): 4.52e-42: 136: 39.13		Q91XK1_MOUSE (193-706): 0: 579: 61.03
+	Mm
		627916 ID1_MOUSE (3-100): 7.66e-41: 134: 46.60		Q91XK1_MOUSE (193-706): 0: 579: 61.03
+	Hs
		117291 ID1_HUMAN (1-100): 2.58e-43: 140: 47.22		K7EMM4_HUMAN (479-706): 1.42e-97: 301: 49.57