HitPredict

Interactor 1: TUP1 (P16649)
General transcriptional corepressor TUP1 (Flocculation suppressor protein) (Glucose repression regulatory protein TUP1) (Repressor AER2)
Gene: TUP1

Interactor 2: TUP1 (P16649)
General transcriptional corepressor TUP1 (Flocculation suppressor protein) (Glucose repression regulatory protein TUP1) (Repressor AER2)
Gene: TUP1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.865

The method score is based on:

Property Details
Experiments 11967834, 10722750, 22707714, 22875988
Identification Methods unspecified method, pull down, x-ray crystallography, two hybrid
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Tup_N~Tup_N, WD40~WD40
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0000278 - mitotic cell cycle
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 14 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 713
Sc

1 713
+ Sp
+ Ce
+ Hs
+ Sp
+ Hs
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Sc
+ Hs
+ Dm

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Last updated: 11Aug2025