HitPredict

Interactor 1: GHR (P16882)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Interactor 2: STAT3 (P42227)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Mus musculus

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8923468
Identification Methods	biophysical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0040014 - regulation of multicellular organism growth GO:0060397 - growth hormone receptor signaling pathway via JAK-STAT
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 650 Mm			1 770
+	Hs
		533835 GHR_HUMAN (1-649): 0: 666: 68.00		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Mm
		599255 GHR_MOUSE (1-650): 0: 753: 100.00		STA5B_MOUSE (1-734): 0: 760: 30.59
+	Mm
		599254 GHR_MOUSE (1-650): 0: 753: 100.00		STA5A_MOUSE (1-734): 0: 758: 30.46
+	Hs
		533838 GHR_HUMAN (1-649): 0: 666: 68.00		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		575813 IL2RB_HUMAN (50-490): 8.17e-65: 225: 14.99		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		599170 IL7RA_HUMAN (115-453): 7.36e-53: 190: 16.67		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		827902 CSF3R_HUMAN (26-273): 1.17e-40: 160: 15.12		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		575815 IL2RB_HUMAN (50-490): 8.17e-65: 225: 14.99		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		596943 PRLR_HUMAN (44-537): 1.54e-123: 381: 26.42		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		599174 IL7RA_HUMAN (115-453): 7.36e-53: 190: 16.67		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		575827 IL2RB_HUMAN (50-490): 8.17e-65: 225: 14.99		STAT4_HUMAN (1-729): 0: 893: 48.44
+	Hs
		838095 I13R2_HUMAN (23-291): 5.5e-44: 163: 16.25		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Mm
		838404 PRLR_MOUSE (34-482): 1.5e-100: 321: 26.25		STA5A_MOUSE (1-734): 0: 758: 30.46
+	Hs
		1132029 I12R2_HUMAN (44-265): 7.9e-36: 146: 18.14		STAT4_HUMAN (1-729): 0: 893: 48.44
+	Mm
		593806 IL2RB_MOUSE (54-483): 5.56e-69: 235: 10.34		STA5B_MOUSE (1-734): 0: 760: 30.59
+	Mm
		593805 IL2RB_MOUSE (54-483): 5.56e-69: 235: 10.34		STA5A_MOUSE (1-734): 0: 758: 30.46
+	Hs
		575819 IL2RB_HUMAN (50-490): 8.17e-65: 225: 14.99		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		575816 IL2RB_HUMAN (50-490): 8.17e-65: 225: 14.99		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		599175 IL7RA_HUMAN (115-453): 7.36e-53: 190: 16.67		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		619211 EPOR_HUMAN (49-456): 7.71e-50: 183: 15.62		STA5A_HUMAN (1-734): 0: 745: 30.42