Protein: GHR
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

Gene: GHR
Organism: Homo sapiens
Interactions: 49
UniProt ID: P10912

Gene Ontology (top 5):
GO:0004903 - growth hormone receptor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

377164

SOMA
Somatotropin

7

2

Small-scale

0.961

High

155069

SOCS2
Suppressor of cytokine signaling 2

6

20

Small-scale

0.937

High

253279

JAK2
Tyrosine-protein kinase JAK2

4

20

Small-scale

0.873

High

533844

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.865

High

533861

FBW1A
F-box/WD repeat-containing protein 1A

3

6

Small-scale

0.861

High

533830

PTPRB
Receptor-type tyrosine-protein phosphatase beta

2

17

Small-scale

0.802

High

533858

CISH
Cytokine-inducible SH2-containing protein

2

20

Small-scale

0.792

High

533826

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

20

Small-scale

0.770

High

533827

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.770

High

533831

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

16

Small-scale

0.770

High

533828

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

7

Small-scale

0.768

High

533840

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.768

High

533857

PTPRH
Receptor-type tyrosine-protein phosphatase H

1

18

Small-scale

0.757

High

533824

GHR
Growth hormone receptor

2

16

Small-scale

0.737

High

533854

DUS7
Dual specificity protein phosphatase 7

1

1

Small-scale

0.734

High

193190

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.724

High

533836

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

20

Small-scale

0.669

High

136271

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

Small-scale

0.647

High

155901

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.647

High

533833

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.647

High

533835

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.647

High

533838

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.647

High

533846

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

Small-scale

0.647

High

465379

IGF1R
Insulin-like growth factor 1 receptor

1

10

Small-scale

0.618

High

533825

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

533829

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

533832

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.618

High

533834

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

533837

CRK
Adapter molecule crk

1

20

High-throughput

0.618

High

533847

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.618

High

533842

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.614

High

471713

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.575

High

533843

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.575

High

533845

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

19

High-throughput

0.575

High

533850

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

17

High-throughput

0.575

High

533862

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

20

High-throughput

0.575

High

226688

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

6

Small-scale

0.561

High

533860

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

Small-scale

0.561

High

533841

SKP1
S-phase kinase-associated protein 1

2

0

Small-scale

0.539

High

533852

ELOB
Elongin-B

1

1

Small-scale

0.527

High

533853

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.500

High

533849

NCOA6
Nuclear receptor coactivator 6

1

1

Small-scale

0.457

High

533839

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.408

High

533848

CUL1
Cullin-1

1

3

Small-scale

0.408

High

533851

ELOC
Elongin-C

1

1

Small-scale

0.408

High

533856

CUL5
Cullin-5

1

3

Small-scale

0.408

High

533859

RBX2
RING-box protein 2

1

1

Small-scale

0.408

High

533855

FBX31
F-box only protein 31

1

0

Small-scale

0.391

High


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Last updated: 11Aug2025