Protein: IL2RB
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)

Gene: IL2RB
Organism: Homo sapiens
Interactions: 32
UniProt ID: P14784

Gene Ontology (top 5):
GO:0004896 - cytokine receptor activity
GO:0004911 - interleukin-2 receptor activity
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575822

IL2
Interleukin-2

7

2

Small-scale

0.962

High

575814

IL15
Interleukin-15

5

1

Small-scale

0.920

High

575808

JAK1
Tyrosine-protein kinase JAK1

9

20

Small-scale

0.749

High

575812

IL2RG
Cytokine receptor common subunit gamma

8

19

Small-scale

0.748

High

378603

IL2RA
Interleukin-2 receptor subunit alpha

4

2

Small-scale

0.676

High

575816

STA5A
Signal transducer and activator of transcription 5A

3

20

Small-scale

0.651

High

169420

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

10

Small-scale

0.646

High

193196

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.631

High

575819

STA5B
Signal transducer and activator of transcription 5B

2

20

Small-scale

0.602

High

575811

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.595

High

575820

JAK3
Tyrosine-protein kinase JAK3

2

20

Small-scale

0.584

High

575829

PCH2
Pachytene checkpoint protein 2 homolog

2

3

High-throughput

0.553

High

575828

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.516

High

575832

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.515

High

155902

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.501

High

575813

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.501

High

575815

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.501

High

575823

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.501

High

575824

RACK1
Small ribosomal subunit protein RACK1

1

4

Small-scale

0.501

High

253284

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.479

High

400228

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

Small-scale

0.479

High

439931

LCK
Tyrosine-protein kinase Lck

1

19

Small-scale

0.479

High

575809

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

17

Small-scale

0.479

High

575810

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

Small-scale

0.479

High

575817

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.479

High

575821

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.479

High

575825

ACTS
Actin, alpha skeletal muscle

1

4

Small-scale

0.479

High

575827

STAT4
Signal transducer and activator of transcription 4

1

20

Small-scale

0.479

High

575830

ECM1
Extracellular matrix protein 1

1

1

Small-scale

0.479

High

575831

TBA1A
Tubulin alpha-1A chain

1

16

Small-scale

0.479

High

575818

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

575826

I15RA
Interleukin-15 receptor subunit alpha

1

0

Small-scale

0.458

High


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Last updated: 11Aug2025