HitPredict

Interactor 1: YBOX3 (P16989)
Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)
Gene: YBX3

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	26167880, unassigned3799
Identification Methods	enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 688
+	Hs
		599864 YBOX3_HUMAN (1-372): 8.14e-79: 248: 100.00		SRPK1_HUMAN (27-688): 2.64e-125: 388: 53.00
+	Hs
		1006490 LN28B_HUMAN (63-314): 9.75e-58: 190: 22.39		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		994464 YBOX1_HUMAN (58-372): 1.89e-52: 178: 45.89		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		1006806 YBOX2_HUMAN (58-366): 4.56e-50: 173: 42.54		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		1006726 LN28A_HUMAN (82-256): 3.88e-42: 148: 25.82		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		1402589 LN28A_HUMAN (82-256): 3.88e-42: 148: 25.82		SRPK1_HUMAN (27-688): 2.64e-125: 388: 53.00
+	Hs
		599696 YBOX3_HUMAN (1-372): 8.14e-79: 248: 100.00		CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83
+	Hs
		599907 YBOX3_HUMAN (1-372): 8.14e-79: 248: 100.00		SRPK3_HUMAN (453-687): 8.64e-64: 223: 67.23
+	Hs
		908092 YBOX1_HUMAN (58-372): 1.89e-52: 178: 45.89		KS6A3_HUMAN (2-362): 2.76e-77: 264: 13.83
+	Hs
		994550 YBOX1_HUMAN (58-372): 1.89e-52: 178: 45.89		KS6A1_HUMAN (2-343): 1.95e-75: 259: 14.76
+	Hs
		889840 YBOX2_HUMAN (58-366): 4.56e-50: 173: 42.54		CLK3_HUMAN (62-240): 8.41e-62: 216: 31.11
+	Hs
		889814 LN28A_HUMAN (82-256): 3.88e-42: 148: 25.82		CLK3_HUMAN (62-240): 8.41e-62: 216: 31.11
+	Hs
		1119706 LN28A_HUMAN (82-256): 3.88e-42: 148: 25.82		CDK13_HUMAN (373-687): 6.51e-56: 208: 15.85
+	Hs
		1437374 LN28A_HUMAN (82-256): 3.88e-42: 148: 25.82		CDK12_HUMAN (347-687): 1.01e-55: 208: 14.97
+	Ce
		1018981 P91306_CAEEL (78-233): 1.61e-41: 148: 39.49		SPK1_CAEEL (459-686): 7.27e-54: 201: 49.39
+	Dm
		1377297 Q95RE4_DROME (79-229): 1.34e-33: 129: 53.64		Q9VR61_DROME (69-348): 1.17e-36: 149: 15.39