HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: RHG21 (Q5T5U3)
Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)
Gene: ARHGAP21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 1958
+	Hs
		1213085 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		RHG21_HUMAN (1-1958): 0: 1825: 100.00
+	Hs
		1433529 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		RHG35_HUMAN (750-1363): 6.84e-88: 320: 18.70
+	Ca
		515419 CDC42_CANAL (10-185): 2.9e-86: 254: 67.61		Q5AMQ3_CANAL (285-1339): 9.28e-103: 361: 16.32
+	Hs
		67708 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		RHG32_HUMAN (1097-1662): 1.92e-82: 304: 20.34
+	Mm
		1282996 RHOJ_MOUSE (9-185): 3.9e-105: 303: 83.05		RHG33_MOUSE (1127-1720): 7.04e-85: 308: 18.57
+	Hs
		1092743 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		RHG05_HUMAN (1021-1361): 1.45e-67: 255: 21.78
+	Hs
		67612 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		RHG32_HUMAN (1097-1662): 1.92e-82: 304: 20.34
+	Sc
		618347 CDC42_YEAST (10-185): 5.83e-85: 251: 66.48		RGA1_YEAST (540-1338): 3.69e-82: 295: 15.44
+	Mm
		988897 RAC1_MOUSE (10-195): 2.03e-80: 239: 63.98		RHG32_MOUSE (1097-1662): 7.53e-83: 306: 21.14
+	Hs
		67650 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		RHG32_HUMAN (1097-1662): 1.92e-82: 304: 20.34
+	Hs
		212765 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		SRGP3_HUMAN (742-1735): 5.19e-84: 303: 13.92
+	Hs
		269508 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		SRGP2_HUMAN (1027-1640): 1.23e-80: 292: 18.09
+	Mm
		988900 RAC1_MOUSE (10-195): 2.03e-80: 239: 63.98		RHG22_MOUSE (988-1672): 4.49e-83: 291: 16.88
+	Mm
		988896 RAC1_MOUSE (10-195): 2.03e-80: 239: 63.98		CHIO_MOUSE (1063-1339): 6.23e-86: 286: 27.44
+	Hs
		601263 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		RHG05_HUMAN (1021-1361): 1.45e-67: 255: 21.78
+	Hs
		156404 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		RHG33_HUMAN (1109-1479): 3.38e-65: 246: 21.20
+	Mm
		988887 RAC1_MOUSE (10-195): 2.03e-80: 239: 63.98		ABR_MOUSE (1131-1341): 5.57e-66: 244: 34.70
+	Hs
		65907 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		RHG42_HUMAN (1164-1570): 1.77e-63: 237: 23.15
+	Ce
		110926 CDC42_CAEEL (10-193): 3.52e-91: 266: 67.94		G5ECK6_CAEEL (1142-1334): 4.25e-20: 98.2: 33.82
+	Mm
		988892 RAC1_MOUSE (10-195): 2.03e-80: 239: 63.98		BCR_MOUSE (1142-1311): 4.06e-23: 110: 40.00