Interactor 1: EGLN (P17813)
Endoglin (CD antigen CD105)
Gene: ENG
Interactor 2: ACVL1 (P37023)
Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVRL1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.88 | 0.60 | 0.730 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15702480, 10767348, 23868260, 18333754, 16785228, 28564608 |
| Identification Methods | affinity chromatography technology, coimmunoprecipitation, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, in-gel kinase assay, cross-linking study, pull down |
| Interaction Type | physical association, phosphorylation reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0001937 - negative regulation of endothelial cell proliferation GO:0003203 - endocardial cushion morphogenesis GO:0005886 - plasma membrane GO:0006355 - regulation of DNA-templated transcription GO:0007179 - transforming growth factor beta receptor signaling pathway and 11 others more... |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs |  |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm |  |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
