HitPredict

Interactor 1: KAPCG (P22612)
cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)
Gene: PRKACG

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 457
+	Hs
		568651 KAPCA_HUMAN (1-351): 1.79e-162: 459: 82.91		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		610723 KAPCB_HUMAN (1-351): 1.01e-160: 455: 78.63		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609664 KAPCG_HUMAN (1-351): 6.75e-163: 460: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		682173 AKT2_HUMAN (2-347): 5.57e-150: 432: 35.51		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035058 AKT3_HUMAN (7-347): 3.74e-148: 428: 38.26		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		681830 AKT1_HUMAN (7-347): 4.44e-147: 425: 38.51		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		850786 PRKX_HUMAN (8-351): 2.34e-143: 411: 43.35		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035034 KS6B2_HUMAN (30-351): 2.57e-140: 408: 36.72		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035006 SGK2_HUMAN (1-340): 2.1e-139: 401: 40.58		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		117002 SGK1_HUMAN (7-340): 3.02e-138: 401: 39.53		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		969070 KPCE_HUMAN (4-351): 2.87e-139: 414: 34.07		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		217878 PRKY_HUMAN (45-267): 6.93e-87: 265: 50.22		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		118692 KAPCG_HUMAN (1-351): 6.75e-163: 460: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118712 PRKX_HUMAN (8-351): 2.34e-143: 411: 43.35		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118793 SGK2_HUMAN (1-340): 2.1e-139: 401: 40.58		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		609671 KAPCG_HUMAN (1-351): 6.75e-163: 460: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		568664 KAPCA_HUMAN (1-351): 1.79e-162: 459: 82.91		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		609649 KAPCG_HUMAN (1-351): 6.75e-163: 460: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Rn
		193486 AKT3_RAT (7-343): 4.33e-146: 422: 38.71		STIP1_RAT (265-457): 1.25e-22: 102: 18.14
+	Hs
		1053243 KS6B2_HUMAN (30-351): 2.57e-140: 408: 36.72		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23