HitPredict

Interactor 1: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Interactor 2: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26641092, 21566083
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 707 Hs			1 475
+	Hs
		641756 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00
+	Hs
		516364 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00
+	Hs
		641790 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00
+	Hs
		1031344 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79
+	Hs
		1020249 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42
+	Hs
		613470 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79
+	Hs
		516484 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42
+	Hs
		1031328 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		613455 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		516518 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		1054328 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Mm
		665745 PABP1_MOUSE (287-700): 2.49e-70: 243: 16.67		TIA1_MOUSE (253-475): 4.2e-36: 139: 15.70
+	Hs
		1031490 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50
+	Hs
		516471 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67
+	Hs
		516495 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35
+	Hs
		516730 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50
+	Hs
		516339 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35
+	Hs
		516689 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP3_HUMAN (41-247): 1.1e-18: 91.1: 14.80