HitPredict

Interactor 1: CD33 (P20138)
Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)
Gene: CD33

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.50	0.646

Property	Details
Experiments	10206955, 17008544, 10887109, 17947393
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 364 Hs			1 593
+	Hs
		1053762 SLAF5_HUMAN (4-362): 3.51e-45: 160: 19.11		PTN11_HUMAN (1-593): 0: 598: 100.00
+	Mm
		767025 SIG10_MOUSE (24-311): 2.89e-22: 100: 14.15		PTN11_MOUSE (1-593): 0: 597: 99.49
+	Hs
		1053723 SIG10_HUMAN (74-308): 5.92e-20: 93.4: 12.96		PTN11_HUMAN (1-593): 0: 598: 100.00
+	Hs
		580761 PVR_HUMAN (19-246): 7.85e-18: 86: 19.92		PTN11_HUMAN (1-593): 0: 598: 100.00
+	Hs
		188589 SIGL5_HUMAN (22-363): 3.15e-17: 84.9: 18.46		PTN11_HUMAN (1-593): 0: 598: 100.00
+	Hs
		1053774 SIGL9_HUMAN (109-362): 3.31e-17: 84.5: 21.99		PTN11_HUMAN (1-593): 0: 598: 100.00
+	Hs
		1053772 SIGL7_HUMAN (109-362): 9.34e-14: 74.1: 20.14		PTN11_HUMAN (1-593): 0: 598: 100.00
+	Hs
		1053728 SIG11_HUMAN (27-362): 1.1e-11: 68: 18.38		PTN11_HUMAN (1-593): 0: 598: 100.00
+	Hs
		611079 CXAR_HUMAN (4-354): 1.36e-50: 174: 14.80		PTN1_HUMAN (251-541): 1.08e-112: 345: 33.67
+	Dm
		1409527 Q9BN17_DROME (31-320): 1.02e-20: 96.1: 12.17		Q9W4F5_DROME (191-560): 9.88e-113: 371: 29.38
+	Hs
		471721 CD22_HUMAN (10-254): 9.59e-19: 89.9: 16.73		PTPRC_HUMAN (33-579): 2.61e-82: 283: 17.95
+	Hs
		1144644 PXDN_HUMAN (140-356): 1.78e-29: 121: 10.21		PTPRK_HUMAN (35-524): 1.19e-69: 247: 19.09
+	Hs
		628344 CD33_HUMAN (11-364): 1.08e-85: 265: 100.00		PTN6_HUMAN (2-101): 5.81e-19: 92.6: 36.70
+	Hs
		711177 SIG10_HUMAN (74-308): 5.92e-20: 93.4: 12.96		PTN6_HUMAN (2-101): 5.81e-19: 92.6: 36.70
+	Hs
		629541 CD22_HUMAN (10-254): 9.59e-19: 89.9: 16.73		PTN6_HUMAN (2-101): 5.81e-19: 92.6: 36.70
+	Mm
		711214 CD22_MOUSE (4-254): 2.73e-18: 88.4: 15.02		PTN6_MOUSE (2-185): 4.92e-19: 93: 26.94
+	Hs
		188587 SIGL5_HUMAN (22-363): 3.15e-17: 84.9: 18.46		PTN6_HUMAN (2-101): 5.81e-19: 92.6: 36.70
+	Hs
		711209 SIGL9_HUMAN (109-362): 3.31e-17: 84.5: 21.99		PTN6_HUMAN (2-101): 5.81e-19: 92.6: 36.70
+	Hs
		711207 SIGL7_HUMAN (109-362): 9.34e-14: 74.1: 20.14		PTN6_HUMAN (2-101): 5.81e-19: 92.6: 36.70
+	Hs
		711179 SIG11_HUMAN (27-362): 1.1e-11: 68: 18.38		PTN6_HUMAN (2-101): 5.81e-19: 92.6: 36.70