HitPredict

Interactor 1: A5D6Q2 (A5D6Q2)
Nuclear receptor coactivator 3 (EC 2.3.1.48)
Gene: Ncoa3

Interactor 2: A5D6Q2 (A5D6Q2)
Nuclear receptor coactivator 3 (EC 2.3.1.48)
Gene: Ncoa3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	14611647
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PAS~PAS, PAS~PAS_11, PAS_11~PAS_11
Common GO terms	GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0016922 - nuclear receptor binding GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1353 Mm			1 1353
+	Mm
		148550 NCOA3_MOUSE (1-1353): 7.71e-162: 524: 96.38		NCOA3_MOUSE (1-1353): 7.71e-162: 524: 96.38
+	Xl
		237432 NCOA3_XENLA (1-1353): 3.91e-124: 421: 63.78		NCOA3_XENLA (1-1353): 3.91e-124: 421: 63.78
+	Hs
		1150420 NCOA3_HUMAN (1-1353): 4.02e-144: 477: 80.69		NCOA2_HUMAN (1-1341): 1.11e-97: 346: 37.42
+	Hs
		1161293 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92
+	Hs
		1153801 NCOA3_HUMAN (1-1353): 4.02e-144: 477: 80.69		NCOA1_HUMAN (1-1350): 3.11e-71: 264: 25.29
+	Hs
		1161374 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		EPAS1_HUMAN (2-800): 1.42e-103: 352: 14.85
+	Hs
		1438509 NCOA3_HUMAN (1-1353): 4.02e-144: 477: 80.69		ARNT2_HUMAN (2-578): 1.25e-65: 239: 15.77
+	Mm
		1222566 HIF1A_MOUSE (2-721): 1.03e-114: 382: 13.33		BMAL1_MOUSE (1-482): 8.72e-99: 331: 18.37
+	Hs
		1407035 NCOA3_HUMAN (1-1353): 4.02e-144: 477: 80.69		NPAS2_HUMAN (14-621): 6e-64: 236: 16.80
+	Hs
		132728 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		BMAL1_HUMAN (1-482): 5.92e-97: 326: 18.52
+	Hs
		92030 D0VY79_HUMAN (2-721): 7.29e-111: 371: 12.92		BMAL1_HUMAN (1-482): 5.92e-97: 326: 18.52
+	Mm
		1081348 HIF1A_MOUSE (2-721): 1.03e-114: 382: 13.33		HIF3A_MOUSE (13-417): 1.11e-87: 301: 18.87
+	Hs
		1161449 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		HIF3A_HUMAN (13-558): 1.04e-86: 299: 16.89
+	Hs
		1161460 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		X5DP31_HUMAN (2-538): 2.43e-80: 280: 15.46
+	Hs
		1153763 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		NCOA1_HUMAN (1-1350): 3.11e-71: 264: 25.29
+	Hs
		693288 SIM1_HUMAN (2-693): 2.82e-112: 373: 15.19		ARNT_HUMAN (2-634): 6.74e-72: 259: 15.54
+	Mm
		923315 HIF1A_MOUSE (2-721): 1.03e-114: 382: 13.33		ARNT_MOUSE (2-634): 1.1e-68: 250: 16.11
+	Hs
		693329 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		ARNT_HUMAN (2-634): 6.74e-72: 259: 15.54
+	Hs
		1010419 SIM1_HUMAN (2-693): 2.82e-112: 373: 15.19		ARNT2_HUMAN (2-578): 1.25e-65: 239: 15.77
+	Hs
		1161409 HIF1A_HUMAN (2-721): 7.29e-111: 371: 12.92		ARNT2_HUMAN (2-578): 1.25e-65: 239: 15.77