HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Interactor 2: TRIM1 (Q9UJV3)
Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)
Gene: MID2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 735
+	Hs
		175641 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		TRI18_HUMAN (21-717): 8.76e-175: 518: 72.60
+	Hs
		175657 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		TRI18_HUMAN (21-717): 8.76e-175: 518: 72.60
+	Hs
		637461 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		156314 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		1170911 PSMA8_HUMAN (4-234): 1.7e-93: 277: 32.08		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		656258 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		893695 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		637476 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		TRI42_HUMAN (24-422): 6.87e-73: 252: 22.87
+	Hs
		638153 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		637541 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		TRI54_HUMAN (184-400): 2.63e-53: 190: 23.96
+	Hs
		536731 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		TRI27_HUMAN (16-340): 1.18e-23: 107: 14.15
+	Hs
		637342 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		TRI23_HUMAN (28-272): 6.41e-17: 86.7: 24.71
+	Hs
		893758 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		TRI39_HUMAN (21-389): 6.9e-27: 117: 12.81
+	Hs
		637414 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		TRI14_HUMAN (192-413): 5.06e-11: 67.6: 19.30
+	Hs
		135009 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		TRI38_HUMAN (16-269): 6.94e-21: 98.2: 17.12
+	Hs
		656159 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		TRI23_HUMAN (28-272): 6.41e-17: 86.7: 24.71