HitPredict

Interactor 1: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Interactor 2: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Chromo~SNF2-rel_dom
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 185
+	Hs
		658667 SMCA1_HUMAN (1-1054): 0: 1130: 100.00		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		229384 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		1027145 CHD5_HUMAN (31-961): 0: 800: 28.13		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		1018451 CHD3_HUMAN (31-954): 0: 791: 28.94		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		1027001 CHD4_HUMAN (29-960): 0: 789: 28.27		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		949764 CHD3_HUMAN (31-954): 0: 791: 28.94		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Mm
		1161080 CHD4_MOUSE (29-960): 0: 787: 28.27		Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49
+	Hs
		949784 CHD4_HUMAN (29-960): 0: 789: 28.27		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Mm
		949943 CHD4_MOUSE (29-960): 0: 787: 28.27		CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00
+	Hs
		800360 CHD3_HUMAN (31-954): 0: 791: 28.94		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		1027300 CHD7_HUMAN (3-1046): 0: 780: 26.74		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		800380 CHD4_HUMAN (29-960): 0: 789: 28.27		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		1027277 CHD8_HUMAN (2-1011): 0: 769: 27.72		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		1027026 CHD9_HUMAN (2-1019): 0: 741: 26.94		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		203687 CHD4_HUMAN (29-960): 0: 789: 28.27		SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10
+	Hs
		123245 CHD3_HUMAN (31-954): 0: 791: 28.94		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Hs
		151406 CHD1_HUMAN (5-1050): 0: 695: 29.33		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		123332 CHD7_HUMAN (3-1046): 0: 780: 26.74		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Hs
		846923 SMCA4_HUMAN (60-913): 0: 686: 31.42		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Hs
		800320 SMCA4_HUMAN (60-913): 0: 686: 31.42		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45