HitPredict

Interactor 1: B4DUB1 (B4DUB1)
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6
Gene: B4DUB1

Interactor 2: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Med14~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 1454
+	Hs
		225416 CDK19_HUMAN (3-378): 9.28e-111: 334: 94.15		MED14_HUMAN (1-1454): 0: 1560: 100.00
+	Hs
		225356 CDK8_HUMAN (3-378): 4.08e-109: 329: 65.43		MED14_HUMAN (1-1454): 0: 1560: 100.00
+	Dm
		1373825 CDK8_DROME (3-248): 4.94e-97: 297: 76.42		MED14_DROME (23-1453): 0: 1157: 36.49
+	Sc
		581365 SSN3_YEAST (28-252): 3.4e-42: 156: 41.88		MED14_YEAST (2-463): 8.6e-138: 453: 18.45
+	Hs
		826323 CDK8_HUMAN (3-378): 4.08e-109: 329: 65.43		CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70
+	Hs
		625020 CDK19_HUMAN (3-378): 9.28e-111: 334: 94.15		RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30
+	Hs
		624806 CDK8_HUMAN (3-378): 4.08e-109: 329: 65.43		RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30
+	Hs
		658971 MK01_HUMAN (2-256): 2.6e-89: 275: 28.79		TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14
+	Dm
		375670 CDK8_DROME (3-248): 4.94e-97: 297: 76.42		RPB1_DROME (1020-1358): 1.57e-09: 64.9: 10.10
+	Rn
		926487 MK01_RAT (2-256): 2.36e-89: 275: 28.79		SYNJ1_RAT (909-1337): 2.07e-14: 81.1: 11.93
+	Hs
		647643 MK03_HUMAN (2-258): 3.74e-89: 275: 30.89		CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70
+	Hs
		659020 MK01_HUMAN (2-256): 2.6e-89: 275: 28.79		CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70
+	Hs
		625532 CDK2_HUMAN (1-217): 8.2e-86: 263: 34.10		CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70
+	Dm
		772979 ERKA_DROME (2-257): 4.29e-88: 272: 27.91		CANB_DROME (1004-1196): 1.4e-10: 68.3: 23.27
+	Hs
		414876 CDK1_HUMAN (3-214): 3.27e-86: 265: 33.49		IF4G1_HUMAN (840-1368): 3.72e-09: 63.8: 10.72
+	Hs
		123878 CDK7_HUMAN (28-230): 1.6e-29: 118: 38.42		SPT5H_HUMAN (1062-1272): 9.25e-11: 68.8: 14.41
+	Hs
		624813 CDK7_HUMAN (28-230): 1.6e-29: 118: 38.42		RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30