HitPredict

Interactor 1: STAT3 (P42227)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: JAK3 (Q62137)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3)
Gene: JAK3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	22402124, 14976041
Identification Methods	affinity chromatography technology, electrophoretic mobility supershift assay, enzymatic study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0006366 - transcription by RNA polymerase II GO:0019221 - cytokine-mediated signaling pathway GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071345 - cellular response to cytokine stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Mm			1 1100
+	Mm
		838288 STAT3_MOUSE (1-770): 0: 1050: 100.00		JAK2_MOUSE (4-1097): 0: 1020: 47.94
+	Hs
		253318 STAT3_HUMAN (1-770): 0: 1047: 99.87		JAK2_HUMAN (7-1100): 0: 1007: 47.40
+	Hs
		253319 STAT1_HUMAN (1-749): 0: 929: 51.52		JAK2_HUMAN (7-1100): 0: 1007: 47.40
+	Hs
		827692 STAT3_HUMAN (1-770): 0: 1047: 99.87		ABL2_HUMAN (776-1098): 9.51e-96: 332: 31.79
+	Mm
		431331 STAT3_MOUSE (1-770): 0: 1050: 100.00		SRC_MOUSE (811-1099): 3.08e-97: 321: 31.03
+	Hs
		557147 STAT3_HUMAN (1-770): 0: 1047: 99.87		SRC_HUMAN (811-1099): 1.2e-98: 324: 31.38
+	Hs
		439978 STAT3_HUMAN (1-770): 0: 1047: 99.87		LCK_HUMAN (763-1100): 5.31e-97: 319: 29.20
+	Hs
		440422 STAT3_HUMAN (1-770): 0: 1047: 99.87		FYN_HUMAN (786-1099): 5.02e-96: 317: 30.48
+	Hs
		473377 STAT3_HUMAN (1-770): 0: 1047: 99.87		HCK_HUMAN (790-1099): 1.03e-93: 311: 29.58
+	Hs
		463385 STAT3_HUMAN (1-770): 0: 1047: 99.87		LYN_HUMAN (772-1100): 3.37e-92: 306: 27.88
+	Hs
		486666 STAT3_HUMAN (1-770): 0: 1047: 99.87		FGR_HUMAN (811-1099): 5.17e-91: 303: 31.03
+	Hs
		827706 STAT3_HUMAN (1-770): 0: 1047: 99.87		BLK_HUMAN (796-1099): 3.79e-90: 300: 31.05
+	Hs
		827715 STAT3_HUMAN (1-770): 0: 1047: 99.87		JAK3_HUMAN (523-797): 2.98e-63: 236: 19.08
+	Mm
		838277 STAT3_MOUSE (1-770): 0: 1050: 100.00		TIE2_MOUSE (809-1098): 4.44e-39: 160: 33.33
+	Hs
		658648 STAT3_HUMAN (1-770): 0: 1047: 99.87		JAK1_HUMAN (799-1099): 6.57e-38: 156: 20.63
+	Hs
		362902 STAT3_HUMAN (1-770): 0: 1047: 99.87		EGFR_HUMAN (523-796): 1.18e-15: 84.3: 23.35
+	Hs
		463916 STAT3_HUMAN (1-770): 0: 1047: 99.87		RET_HUMAN (513-789): 1.01e-12: 74.7: 22.40
+	Mm
		838272 STAT3_MOUSE (1-770): 0: 1050: 100.00		ERBB2_MOUSE (498-774): 5.63e-11: 69.3: 23.96
+	Hs
		410680 STAT3_HUMAN (1-770): 0: 1047: 99.87		ERBB2_HUMAN (498-774): 2.12e-11: 70.5: 24.31
+	Hs
		541379 STAT3_HUMAN (1-770): 0: 1047: 99.87		FGFR1_HUMAN (512-803): 3.31e-09: 63.2: 22.63