HitPredict

Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: NALP7 (Q8WX94)
NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3)
Gene: NLRP7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	15817483
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0050727 - regulation of inflammatory response GO:0071222 - cellular response to lipopolysaccharide GO:0089720 - caspase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 980
+	Hs
		667478 CASP1_HUMAN (1-404): 0: 514: 100.00		NAL10_HUMAN (1-584): 1.26e-150: 462: 28.24
+	Hs
		667491 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRC4_HUMAN (135-974): 9e-82: 288: 15.21
+	Mm
		667124 CASP1_MOUSE (1-404): 1.52e-165: 471: 62.13		NLRC4_MOUSE (135-974): 4.81e-82: 289: 15.59
+	Hs
		667484 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRP3_HUMAN (566-908): 1.97e-41: 167: 25.58
+	Hs
		667448 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRP6_HUMAN (800-974): 3.07e-19: 95.5: 32.77
+	Hs
		667493 CASP1_HUMAN (1-404): 0: 514: 100.00		NALP2_HUMAN (778-980): 3.83e-17: 88.9: 27.32
+	Hs
		667490 CASP1_HUMAN (1-404): 0: 514: 100.00		NOD2_HUMAN (560-817): 6.59e-17: 88.2: 15.47
+	Hs
		667501 CASP1_HUMAN (1-404): 0: 514: 100.00		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Mm
		667128 CASP1_MOUSE (1-404): 1.52e-165: 471: 62.13		NLRP3_MOUSE (825-980): 8.44e-24: 110: 32.48
+	Hs
		667487 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRP1_HUMAN (871-980): 3.06e-09: 63.5: 24.32
+	Mm
		667127 CASP1_MOUSE (1-404): 1.52e-165: 471: 62.13		NOD2_MOUSE (765-979): 3.87e-18: 92: 20.47
+	Hs
		830296 CASP4_HUMAN (1-404): 6.94e-153: 438: 48.40		NOD2_HUMAN (560-817): 6.59e-17: 88.2: 15.47
+	Hs
		830305 CASP4_HUMAN (1-404): 6.94e-153: 438: 48.40		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Hs
		851077 CASP5_HUMAN (5-404): 1.04e-145: 422: 46.25		NLRP1_HUMAN (871-980): 3.06e-09: 63.5: 24.32
+	Hs
		877005 CASP9_HUMAN (17-399): 9.64e-122: 360: 22.98		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Hs
		876977 CASP9_HUMAN (17-399): 9.64e-122: 360: 22.98		BIRC1_HUMAN (531-882): 1.29e-13: 77.8: 13.48
+	Hs
		788267 CASP2_HUMAN (32-404): 3.11e-117: 350: 24.57		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Hs
		877001 CASP9_HUMAN (17-399): 9.64e-122: 360: 22.98		NLRP1_HUMAN (871-980): 3.06e-09: 63.5: 24.32
+	Hs
		788263 CASP2_HUMAN (32-404): 3.11e-117: 350: 24.57		NLRP1_HUMAN (871-980): 3.06e-09: 63.5: 24.32
+	Hs
		1166744 CASPC_HUMAN (138-404): 4.34e-104: 313: 51.67		NOD2_HUMAN (560-817): 6.59e-17: 88.2: 15.47