HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24869908
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Hs			1 519
+	Hs
		153882 AKT1_HUMAN (1-480): 0: 586: 100.00		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Rn
		404387 KPCA_RAT (14-477): 1.16e-151: 449: 36.27		DLG4_RAT (3-344): 2.03e-36: 145: 17.22
+	Hs
		566353 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22
+	Mm
		934625 KPCB_MOUSE (14-477): 1.87e-148: 440: 36.46		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Rn
		404390 KPCA_RAT (14-477): 1.16e-151: 449: 36.27		DLG3_RAT (3-359): 6.78e-32: 132: 17.27
+	Mm
		554913 KPCE_MOUSE (53-474): 8.58e-146: 436: 39.53		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Hs
		153871 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		566437 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74
+	Hs
		566388 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		566396 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Mm
		934628 KPCB_MOUSE (14-477): 1.87e-148: 440: 36.46		INADL_MOUSE (2-120): 5.89e-17: 86.7: 15.32
+	Hs
		117007 SGK1_HUMAN (104-478): 5.29e-146: 426: 44.97		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		566427 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		LNX2_HUMAN (273-487): 1.94e-10: 65.6: 12.33
+	Mm
		1143553 KS6A2_MOUSE (85-452): 4.7e-97: 309: 25.65		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Hs
		153900 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		850651 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		850657 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		1049957 KS6A2_HUMAN (85-452): 6.82e-94: 301: 25.39		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		1021498 KS6A2_HUMAN (85-452): 6.82e-94: 301: 25.39		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Dm
		54646 APKC_DROME (142-474): 2.58e-98: 309: 43.90		DLG1_DROME (4-85): 3.78e-12: 71: 30.12