HitPredict

Interactor 1: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 359
+	Hs
		1229366 LHX8_HUMAN (24-148): 1.11e-47: 159: 33.60		ISL2_HUMAN (1-359): 6.76e-85: 262: 100.00
+	Hs
		961488 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		ISL1_HUMAN (14-358): 2.62e-86: 266: 73.91
+	Dm
		120439 P92031_DROME (24-153): 1.22e-45: 157: 34.09		M9PD53_DROME (2-265): 7.25e-52: 182: 32.08
+	Dm
		1477947 Q9VJ37_DROME (24-153): 1.04e-45: 158: 34.09		Q9VJ00_DROME (2-265): 7.58e-52: 181: 32.08
+	Hs
		965470 LHX8_HUMAN (24-148): 1.11e-47: 159: 33.60		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Hs
		895773 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		LHX2_HUMAN (24-326): 9.55e-57: 191: 27.20
+	Hs
		965498 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Hs
		1347343 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		LMO3_HUMAN (27-148): 1.54e-26: 104: 40.16
+	Hs
		682083 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		RBTN1_HUMAN (27-143): 3.29e-26: 103: 40.83
+	Dm
		118261 Q9VJ37_DROME (24-153): 1.04e-45: 158: 34.09		M9NCY1_DROME (1-83): 1.54e-15: 79.2: 26.19
+	Ce
		110438 LIM7_CAEEL (14-147): 4.16e-45: 155: 33.82		HM14_CAEEL (7-90): 5.51e-14: 74.2: 18.61
+	Mm
		923326 ISL2_MOUSE (12-148): 2.54e-41: 143: 32.61		LHX4_MOUSE (1-82): 2.25e-17: 84.6: 22.89
+	Hs
		1379927 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		LHX4_HUMAN (1-82): 2.52e-17: 84.3: 22.89
+	Hs
		1229379 LHX8_HUMAN (24-148): 1.11e-47: 159: 33.60		LHX6_HUMAN (7-81): 1.16e-11: 67.3: 20.00
+	Hs
		253022 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		LMX1B_HUMAN (7-83): 3.21e-16: 81.2: 19.48
+	Ce
		110437 LIM7_CAEEL (14-147): 4.16e-45: 155: 33.82		LIN11_CAEEL (7-82): 7.71e-12: 68.1: 16.88
+	Hs
		1382434 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		877543 ISL2_HUMAN (12-148): 1.68e-41: 143: 32.61		LHX1_HUMAN (7-81): 3.85e-14: 75: 19.74
+	Dm
		120077 M9PCA3_DROME (9-154): 9.55e-41: 145: 32.65		M9PCA3_DROME (7-80): 2.63e-11: 66.9: 21.33