HitPredict

Interactor 1: A0A087WW66 (A0A087WW66)
26S proteasome non-ATPase regulatory subunit 1
Gene: PSMD1

Interactor 2: PSA5 (P28066)
Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)
Gene: PSMA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 914 Hs			1 241
+	Hs
		656297 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00
+	Hs
		686 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96
+	Hs
		685 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSA1_HUMAN (3-241): 1.03e-88: 264: 28.81
+	Hs
		699 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSA6_HUMAN (4-241): 1.93e-88: 263: 25.93
+	Hs
		637734 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96
+	Hs
		156342 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA7_HUMAN (8-239): 7.45e-89: 264: 36.17
+	Hs
		637529 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA1_HUMAN (3-241): 1.03e-88: 264: 28.81
+	Hs
		893734 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA6_HUMAN (4-241): 1.93e-88: 263: 25.93
+	Dm
		1278636 PSMD1_DROME (2-894): 0: 1056: 58.84		PSA5_DROME (1-241): 1.3e-103: 301: 70.37
+	Dm
		771308 PSMD1_DROME (2-894): 0: 1056: 58.84		PSA2_DROME (3-241): 1.55e-99: 291: 31.38
+	Sc
		689159 RPN2_YEAST (2-914): 0: 919: 38.04		PSA5_YEAST (1-241): 7.4e-95: 280: 60.49
+	Sp
		251850 RPN2_SCHPO (1-914): 0: 973: 42.15		PSA4_SCHPO (6-241): 6.82e-44: 150: 34.03
+	Sc
		619340 RPN2_YEAST (2-914): 0: 919: 38.04		PSA3_YEAST (8-238): 3.6e-44: 150: 36.40
+	Hs
		656214 PSMD2_HUMAN (8-712): 0: 704: 20.00		PSA5_HUMAN (1-241): 1.49e-107: 311: 100.00
+	Hs
		637679 PSMD2_HUMAN (8-712): 0: 704: 20.00		PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96
+	Hs
		156281 PSMD2_HUMAN (8-712): 0: 704: 20.00		PSA7_HUMAN (8-239): 7.45e-89: 264: 36.17
+	Hs
		637407 PSMD2_HUMAN (8-712): 0: 704: 20.00		PSA1_HUMAN (3-241): 1.03e-88: 264: 28.81
+	Hs
		893662 PSMD2_HUMAN (8-712): 0: 704: 20.00		PSA6_HUMAN (4-241): 1.93e-88: 263: 25.93
+	Dm
		1278652 Q9VW54_DROME (12-712): 0: 614: 18.02		PSA5_DROME (1-241): 1.3e-103: 301: 70.37
+	Dm
		771325 Q9VW54_DROME (12-712): 0: 614: 18.02		PSA2_DROME (3-241): 1.55e-99: 291: 31.38