HitPredict

Interactor 1: RPN2 (P32565)
26S proteasome regulatory subunit RPN2
Gene: RPN2

Interactor 2: PRS6B (P33298)
26S proteasome regulatory subunit 6B homolog (Protein YNT1) (Tat-binding homolog 2)
Gene: RPT3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	11805837, 24013205, 26301997, 36621624, 37968396, 16554755, 22237024, 22940862
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, pull down, x-ray crystallography, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 945 Sc			1 428
+	At
		221383 PSD1A_ARATH (3-945): 0: 1140: 37.03		PRS4A_ARATH (44-419): 3.53e-159: 457: 46.83
+	At
		1341469 PSD1B_ARATH (3-945): 0: 1120: 37.70		PRS4A_ARATH (44-419): 3.53e-159: 457: 46.83
+	Hs
		906907 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PRS4_HUMAN (15-427): 5.03e-128: 378: 44.34
+	Hs
		798739 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PRS6B_HUMAN (1-424): 2.6e-125: 371: 65.57
+	Hs
		913340 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PRS10_HUMAN (41-426): 2.56e-123: 364: 37.57
+	Hs
		907132 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PRS8_HUMAN (30-423): 3.39e-120: 357: 39.59
+	Sc
		693312 RPN2_YEAST (1-945): 0: 1119: 100.00		PRS4_YEAST (49-410): 4.56e-110: 332: 47.53
+	Dm
		820502 PSMD1_DROME (1-927): 0: 990: 36.04		PRS4_DROME (17-427): 3.74e-136: 399: 44.10
+	Hs
		693 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PRS6B_HUMAN (1-424): 2.6e-125: 371: 65.57
+	Hs
		701 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PRS10_HUMAN (41-426): 2.56e-123: 364: 37.57
+	Hs
		700 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PRS8_HUMAN (30-423): 3.39e-120: 357: 39.59
+	Dm
		1359001 PSMD1_DROME (1-927): 0: 990: 36.04		Q9V405_DROME (28-424): 1.01e-123: 366: 69.42
+	Sp
		251840 RPN2_SCHPO (3-938): 0: 1002: 41.56		PRS6B_SCHPO (40-428): 1.77e-119: 354: 77.89
+	Dm
		186132 PSMD1_DROME (1-927): 0: 990: 36.04		PRS8_DROME (32-423): 7.65e-123: 364: 40.05
+	Dm
		1359019 PSMD1_DROME (1-927): 0: 990: 36.04		Q9W414_DROME (41-426): 1.57e-121: 360: 39.90
+	Sp
		251844 RPN2_SCHPO (3-938): 0: 1002: 41.56		PRS4_SCHPO (49-419): 7.63e-113: 340: 49.33
+	Hs
		906819 PSMD2_HUMAN (9-770): 0: 760: 17.31		PRS4_HUMAN (15-427): 5.03e-128: 378: 44.34
+	Hs
		66339 PSMD2_HUMAN (9-770): 0: 760: 17.31		A8K2M0_HUMAN (1-424): 2.6e-125: 371: 65.57
+	Hs
		798648 PSMD2_HUMAN (9-770): 0: 760: 17.31		PRS6B_HUMAN (1-424): 2.6e-125: 371: 65.57
+	Hs
		907011 PSMD2_HUMAN (9-770): 0: 760: 17.31		PRS8_HUMAN (30-423): 3.39e-120: 357: 39.59