HitPredict

Interactor 1: MCM2 (P29469)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)
Gene: MCM2

Interactor 2: MCM4 (P30665)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54)
Gene: MCM4

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 26222030, 23851460, 24805245, 25172955, 32701054, 30104407, 37968396, 22250202, 22421151, 24307213, 23499444, 26255844, 26686640, 26250113, 32415104, 31728581, 18719252, 19910927, 19661920, 19896182 and 4 others

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Identification Methods anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down, affinity chromatography technology, two hybrid, biochemical
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM4_WHD, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM4_WHD~MCM_lid, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0003688 - DNA replication origin binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 14 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 868
Sc

1 933
+ Hs
+ Xl
+ Sp
+ Dm
+ Sc
+ Hs
+ Sc
+ Sc
+ Hs
+ Hs
+ Xl
+ Xl
+ Xl
+ Hs
+ Dm
+ Sp
+ Dm
+ At
+ Sc
+ Sp

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Last updated: 11Aug2025