Protein: MCM6
DNA replication licensing factor MCM6 (EC 3.6.4.12) (Minichromosome maintenance protein 6)

Gene: MCM6
Organism: Saccharomyces cerevisiae S288C
Interactions: 139
UniProt ID: P53091

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

721391

MCM4
DNA replication licensing factor MCM4

22

20

Small-scale

0.988

High

917071

CDC45
Cell division control protein 45

15

18

Small-scale

0.981

High

713011

MCM2
DNA replication licensing factor MCM2

13

20

Small-scale

0.980

High

917056

SLD5
DNA replication complex GINS protein SLD5

15

16

Small-scale

0.979

High

865455

CDT1
Cell division cycle protein CDT1

9

3

Small-scale

0.972

High

664450

MCM3
DNA replication licensing factor MCM3

9

20

Small-scale

0.970

High

713284

MCM5
Minichromosome maintenance protein 5

8

19

Small-scale

0.956

High

794087

MCM7
DNA replication licensing factor MCM7

7

20

Small-scale

0.950

High

917081

PSF1
DNA replication complex GINS protein PSF1

4

11

Small-scale

0.885

High

917074

PSF3
DNA replication complex GINS protein PSF3

3

9

Small-scale

0.840

High

823314

PSF2
DNA replication complex GINS protein PSF2

2

11

Small-scale

0.778

High

735394

MCM10
Minichromosome maintenance protein 10

9

14

Small-scale

0.758

High

440957

CDC7
Cell division control protein 7

7

20

Small-scale

0.744

High

917038

SLD3
DNA replication regulator SLD3

5

3

Small-scale

0.710

High

917051

CTF4
DNA polymerase alpha-binding protein

4

9

Small-scale

0.676

High

917042

TOF1
Topoisomerase 1-associated factor 1

3

9

Small-scale

0.656

High

642061

DPOE
DNA polymerase epsilon catalytic subunit A

1

11

Small-scale

0.647

High

917044

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.647

High

734269

DBF4
DDK kinase regulatory subunit DBF4

2

3

Small-scale

0.625

High

603515

VATA
V-type proton ATPase catalytic subunit A

2

5

High-throughput

0.588

High

917059

RPN9
26S proteasome regulatory subunit RPN9

2

1

High-throughput

0.588

High

677690

MRC1
Mediator of replication checkpoint protein 1

2

3

Small-scale

0.584

High

917063

CSM3
Chromosome segregation in meiosis protein 3

2

3

Small-scale

0.584

High

898168

ORC5
Origin recognition complex subunit 5

1

7

Small-scale

0.575

High

917045

ORC4
Origin recognition complex subunit 4

1

20

Small-scale

0.575

High

365124

KPYK1
Pyruvate kinase 1

2

5

High-throughput

0.571

High

527209

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.571

High

545604

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.571

High

763942

SPT10
Protein SPT10

2

3

High-throughput

0.571

High

836795

MPG1
Mannose-1-phosphate guanyltransferase

2

2

High-throughput

0.571

High

917048

H3
Histone H3

2

20

High-throughput

0.571

High

449420

SPT2
Protein SPT2

2

0

Small-scale

0.570

High

674729

RS2
Small ribosomal subunit protein uS5

2

0

Small-scale

0.559

High

382226

H4
Histone H4

2

8

High-throughput

0.552

High

744890

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

2

High-throughput

0.541

High

792423

BOI1
BEM1-interacting protein 1

1

7

High-throughput

0.541

High

805413

BZZ1
Protein BZZ1

1

2

High-throughput

0.541

High

814235

RV167
Reduced viability upon starvation protein 167

1

4

High-throughput

0.541

High

850447

LSB3
LAS seventeen-binding protein 3

1

4

High-throughput

0.541

High

917061

MYO5
Myosin-5

1

7

High-throughput

0.541

High

917065

CYK2
Cytokinesis protein 2

1

3

High-throughput

0.541

High

917067

PIN3
[PSI+] inducibility protein 3

1

6

High-throughput

0.541

High

722106

XPO1
Exportin-1

1

3

High-throughput

0.536

High

762993

SPT7
SAGA complex subunit SPT7

1

6

High-throughput

0.536

High

917055

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.536

High

739698

SPT16
FACT complex subunit SPT16

2

5

Small-scale

0.533

High

668401

PSB2
Proteasome subunit beta type-2

1

3

High-throughput

0.515

High

917077

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

740595

IME2
Meiosis induction protein kinase IME2/SME1

1

17

Small-scale

0.501

High

745657

ORC2
Origin recognition complex subunit 2

1

9

Small-scale

0.501

High

758509

SLD2
DNA replication regulator SLD2

1

3

Small-scale

0.501

High

603082

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.486

High

677486

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.486

High

444781

SIR2
NAD-dependent histone deacetylase SIR2

1

14

Small-scale

0.481

High

808237

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

3

Small-scale

0.481

High

824853

NDC80
Kinetochore protein NDC80

1

14

Small-scale

0.481

High

824972

CSM2
Chromosome segregation in meiosis protein 2

1

3

Small-scale

0.481

High

917069

NOC3
Nucleolar complex-associated protein 3

1

1

Small-scale

0.481

High

917078

PSY3
Platinum sensitivity protein 3

1

3

Small-scale

0.481

High

358284

ADH1
Alcohol dehydrogenase 1

1

3

High-throughput

0.479

High

365663

PGK
Phosphoglycerate kinase

1

3

High-throughput

0.479

High

430889

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

6

Small-scale

0.479

High

435233

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

439383

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

464620

PBS2
MAP kinase kinase PBS2

1

10

High-throughput

0.479

High

518339

IF4A
ATP-dependent RNA helicase eIF4A

1

9

High-throughput

0.479

High

579756

HSC82
ATP-dependent molecular chaperone HSC82

1

12

High-throughput

0.479

High

597512

EF3A
Elongation factor 3A

1

7

High-throughput

0.479

High

599051

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

5

High-throughput

0.479

High

647804

RFA1
Replication factor A protein 1

1

8

High-throughput

0.479

High

657112

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.479

High

665191

DPB2
DNA polymerase epsilon subunit B

1

3

Small-scale

0.479

High

688924

RS5
Small ribosomal subunit protein uS7

1

3

High-throughput

0.479

High

707675

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

727189

HS104
Heat shock protein 104

1

5

High-throughput

0.479

High

737912

HOG1
Mitogen-activated protein kinase HOG1

1

11

High-throughput

0.479

High

745814

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

775951

LRG1
Rho-GTPase-activating protein LRG1

1

13

High-throughput

0.479

High

776615

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

778436

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

779291

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.479

High

805982

RT107
Regulator of Ty1 transposition protein 107

1

6

Small-scale

0.479

High

826668

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.479

High

916737

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

917039

CDH1
APC/C activator protein CDH1

1

12

Small-scale

0.479

High

917041

HST2
NAD-dependent protein deacetylase HST2

1

14

High-throughput

0.479

High

917047

ACT
Actin

1

7

High-throughput

0.479

High

917050

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

917052

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

917060

SIZ1
E3 SUMO-protein ligase SIZ1

1

2

High-throughput

0.479

High

917066

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

917068

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

917072

DIA2
Protein DIA2

1

3

Small-scale

0.479

High

917075

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

917076

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

High-throughput

0.479

High

917079

DBP10
ATP-dependent RNA helicase DBP10

1

13

High-throughput

0.479

High

917080

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

917083

CMR1
DNA damage-binding protein CMR1

1

9

High-throughput

0.479

High

395257

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.460

High

438215

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.460

High

871496

ASK10
Activator of SKN7 protein 10

1

0

Small-scale

0.460

High

917046

DAK1
Dihydroxyacetone kinase 1

1

0

High-throughput

0.458

High

917057

SKY1
Serine/threonine-protein kinase SKY1

1

18

High-throughput

0.457

High

381174

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

394741

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

448196

HAP2
Transcriptional activator HAP2

1

2

High-throughput

0.445

High

486261

TBA1
Tubulin alpha-1 chain

1

9

High-throughput

0.445

High

548787

MCM1
Pheromone receptor transcription factor

1

1

High-throughput

0.445

High

592379

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.445

High

645624

AFT1
Iron-regulated transcriptional activator AFT1

1

1

High-throughput

0.445

High

671539

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

671667

SCJ1
DnaJ-related protein SCJ1

1

4

High-throughput

0.445

High

736682

ASF1
Histone chaperone ASF1

1

12

High-throughput

0.445

High

781768

SET3
SET domain-containing protein 3

1

6

High-throughput

0.445

High

917037

HOS2
Probable histone deacetylase HOS2

1

4

High-throughput

0.445

High

917058

GIS1
Transcriptional activator/repressor GIS1

1

9

High-throughput

0.445

High

917070

RSC58
Chromatin structure-remodeling complex protein RSC58

1

1

High-throughput

0.445

High

917082

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.445

High

917084

H2AZ
Histone H2A.Z

1

20

High-throughput

0.445

High

817808

NU157
Nucleoporin NUP157

1

1

Small-scale

0.439

High

917054

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.438

High

368013

ENO2
Enolase 2

1

5

High-throughput

0.437

High

368715

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.437

High

383798

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

433745

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

917043

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.437

High

917049

NUM1
Nuclear migration protein NUM1

1

15

High-throughput

0.437

High

917062

POB3
FACT complex subunit POB3

1

10

Small-scale

0.437

High

917073

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

649991

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

738761

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.426

High

807247

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

858446

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.426

High

863661

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

917040

PESC
Pescadillo homolog

1

0

Small-scale

0.426

High

917064

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.426

High

917053

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

16

High-throughput

0.407

High

818122

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.282

High

149218

FOB1
DNA replication fork-blocking protein FOB1

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025