HitPredict

Interactor 1: PRS7 (P35998)
26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)
Gene: PSMC2

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	25666615, 30442662, 27114451
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 624
+	Hs
		730383 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		798776 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Dm
		1181058 Q7KMQ0_DROME (1-433): 1.08e-142: 416: 91.69		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		730366 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		798782 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Dm
		820528 PRS4_DROME (1-428): 9.23e-138: 403: 39.30		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Mm
		872749 PRS6B_MOUSE (3-425): 5.33e-121: 360: 35.93		UBQL2_MOUSE (1-624): 1.66e-145: 437: 84.01
+	Dm
		186163 PRS8_DROME (29-430): 7.81e-122: 361: 46.52		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		730316 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		730283 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Xl
		804064 PRS8_XENLA (37-430): 2.5e-122: 365: 45.69		BAG6A_XENLA (28-578): 4.07e-61: 222: 15.47
+	Sc
		819481 PRS8_YEAST (16-417): 3.49e-154: 444: 44.53		DSK2_YEAST (32-239): 1.13e-31: 128: 31.19
+	Hs
		798608 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		798721 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Dm
		186166 PRS8_DROME (29-430): 7.81e-122: 361: 46.52		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Hs
		798691 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Dm
		1181036 Q7KMQ0_DROME (1-433): 1.08e-142: 416: 91.69		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Dm
		820508 PRS4_DROME (1-428): 9.23e-138: 403: 39.30		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Hs
		730236 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Sc
		703926 PRS7_YEAST (1-433): 1.68e-127: 378: 69.59		DSK2_YEAST (32-239): 1.13e-31: 128: 31.19