HitPredict

Interactor 1: PRP19 (P32523)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase PRP19)
Gene: PRP19

Interactor 2: RUXG (P40204)
Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)
Gene: SMX2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.673

Property	Details
Experiments	11805826, 11804584, 37968396, 16429126
Identification Methods	tandem affinity purification, biochemical, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 503 Sc			1 77
+	Sc
		739159 PRP19_YEAST (1-503): 4.47e-93: 293: 100.00		LSM1_YEAST (2-75): 6.41e-23: 87.2: 25.97
+	Sc
		739178 PRP19_YEAST (1-503): 4.47e-93: 293: 100.00		LSM7_YEAST (3-76): 9.09e-21: 80.3: 36.15
+	Sp
		152528 PRP19_SCHPO (1-480): 1.36e-82: 266: 20.04		RUXG_SCHPO (2-77): 3.37e-20: 77.6: 46.05
+	Sc
		739182 PRP19_YEAST (1-503): 4.47e-93: 293: 100.00		LSM3_YEAST (1-72): 8.99e-09: 49.1: 25.97
+	Sp
		152550 PRP19_SCHPO (1-480): 1.36e-82: 266: 20.04		RSMB_SCHPO (3-72): 2.3e-09: 51.8: 20.51
+	Hs
		209235 PRP4_HUMAN (293-502): 1.07e-39: 152: 11.87		RUXG_HUMAN (5-77): 7.51e-27: 94.6: 53.43
+	Hs
		71540 PRP4_HUMAN (293-502): 1.07e-39: 152: 11.87		RUXGL_HUMAN (5-77): 8.48e-26: 91.9: 49.32
+	Hs
		209352 PRP4_HUMAN (293-502): 1.07e-39: 152: 11.87		LSM7_HUMAN (3-77): 2.4e-25: 91.5: 35.80
+	Hs
		209180 PRP4_HUMAN (293-502): 1.07e-39: 152: 11.87		LSM8_HUMAN (4-75): 7.26e-20: 77.6: 25.68
+	Hs
		209243 PRP4_HUMAN (293-502): 1.07e-39: 152: 11.87		RSMN_HUMAN (7-71): 7.64e-09: 51.8: 19.18