HitPredict

Interactor 1: PRS7 (P33299)
26S proteasome regulatory subunit 7 homolog (Protein CIM5) (Tat-binding homolog 3)
Gene: RPT1

Interactor 2: PRS10 (P53549)
26S proteasome subunit RPT4 (26S protease subunit SUG2) (Proteasomal cap subunit)
Gene: RPT4

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 24013205, 19412160, 11805826, 26301997, 16429126, 18467557, 36621624, 31778111, 37968396, 31848235, 15917626, 22615397
Identification Methods affinity chromatography technology, pull down, tandem affinity purification, protein complementation assay, biochemical, cross-linking study, dihydrofolate reductase reconstruction
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB_C, AAA_lid_3~AAA_lid_3, AAA~PRS7_OB, PRS7_OB~Prot_ATP_ID_OB_C
Common GO terms GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0008540 - proteasome regulatory particle, base subcomplex
GO:0016887 - ATP hydrolysis activity
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 467
Sc

1 437
+ At
+ At
+ Hs
+ Dm
+ Hs
+ At
+ Sc
+ Dm
+ Hs
+ Hs
+ Rn
+ Hs
+ Dm
+ Dm
+ Sp
+ Sc
+ Sc
+ Sc
+ Hs
+ Sc

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Last updated: 11Aug2025