HitPredict

Interactor 1: RFC4 (P35249)
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)
Gene: RFC4

Interactor 2: RFC5 (P40937)
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
Gene: RFC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 28514442, 29892012, 32296183, 26264872, 9751713, 24981860, 33961781, 25416956, 16189514, 9228079, 30021884, 9488738, 40437099, 9092549, unassigned1304, unassigned3799, 31515488
Identification Methods affinity chromatography technology, two hybrid, biochemical, proximity labelling technology, cross-linking study, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~RCF1-5-like_lid, AAA~Rep_fac_C, RCF1-5-like_lid~Rep_fac_C, Rep_fac_C~Rep_fac_C
Common GO terms GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005663 - DNA replication factor C complex
and 6 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 363
Hs

1 340
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Last updated: 11Aug2025