HitPredict

Interactor 1: RFC2 (P35250)
Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40)
Gene: RFC2

Interactor 2: RFC5 (P40937)
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
Gene: RFC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 28514442, 9751713, 24981860, 33961781, 31839598, 9228079, 35235311, 37071682, unassigned3799
Identification Methods affinity chromatography technology, biochemical, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~RCF1-5-like_lid, AAA~Rep_fac_C, RCF1-5-like_lid~Rep_fac_C, Rep_fac_C~Rep_fac_C
Common GO terms GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005663 - DNA replication factor C complex
and 6 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 354
Hs

1 340
+ Hs
+ Hs
+ Dm
+ At
+ Zm
+ At
+ Dm
+ Hs
+ Ce
+ Sc
+ Dm
+ Sc
+ Hs
+ Hs
+ Dm
+ Sc
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025