Interactor 1: RFC4 (P35249)
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)
Gene: RFC4

Interactor 2: RFC2 (P35250)
Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40)
Gene: RFC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 28514442, 24981860, 33961781, 9092549, 9228079, 9751713, 16582606, 15655353, 9488738, unassigned3799
Identification Methods affinity chromatography technology, pull down, biochemical, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~Rep_fac_C, AAA~RCF1-5-like_lid, RCF1-5-like_lid~Rep_fac_C, Rep_fac_C~Rep_fac_C
Common GO terms GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005663 - DNA replication factor C complex
and 6 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 363
Hs

1 354
+ Hs
+ Hs
+ Zm
+ At
+ Hs
+ Dm
+ Dm
+ Sc
+ At
+ Dm
+ Sc
+ Sc
+ Hs
+ Hs
+ Dm
+ Dm
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025