Interactor 1: RFC4 (P35249)
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)
Gene: RFC4

Interactor 2: RFC3 (P40938)
Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)
Gene: RFC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 32296183, 9488738, 8692848, 31839598, 28514442, 33961781, 37071682, 39358380, 9092549, unassigned1304, unassigned3799
Identification Methods two hybrid, affinity chromatography technology, pull down, cross-linking study, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~DNA_pol3_delta2, AAA~RCF1-5-like_lid, DNA_pol3_delta2~RCF1-5-like_lid, DNA_pol3_delta2~Rep_fac_C, RCF1-5-like_lid~Rep_fac_C, RFC_C~Rep_fac_C
Common GO terms GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005663 - DNA replication factor C complex
GO:0006261 - DNA-templated DNA replication
and 5 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 363
Hs

1 356
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Hs
+ Zm
+ At
+ Dm
+ Dm
+ Sc
+ At
+ Dm
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025