Interactor 1: MLH1 (P40692)
DNA mismatch repair protein Mlh1 (MutL protein homolog 1)
Gene: MLH1
Interactor 2: PMS2 (P54278)
Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2)
Gene: PMS2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.993 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26496610, 11292842, 16338176, 34469738, 17148452, 14676842, 18206974, 12584560, 30770470, 33961781, 10037723, 19015241, 34591612, 37094360, 20978114, 17581638, 10748159, 12799449, 20706999, 15225546 and 10 others
more... |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, two hybrid array, lexa vp16 complementation, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DNA_mis_repair~HATPase_c_3, HATPase_c_3~HATPase_c_3, Mlh1_C~MutL_C |
| Common GO terms | GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006298 - mismatch repair GO:0016446 - somatic hypermutation of immunoglobulin genes and 5 others more... |
| Homologous interactions | 13 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
