Protein: ZHX3
Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3)

Gene: ZHX3
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q9H4I2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1433683

NLK
Serine/threonine-protein kinase NLK

4

1

High-throughput

0.703

High

1433680

ZHX3
Zinc fingers and homeoboxes protein 3

1

14

Small-scale

0.680

High

1433684

ZHX1
Zinc fingers and homeoboxes protein 1

1

18

Small-scale

0.680

High

1433686

ZHX2
Zinc fingers and homeoboxes protein 2

1

15

Small-scale

0.680

High

927547

ATX1
Ataxin-1

2

2

High-throughput

0.620

High

373141

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.618

High

549350

SRF
Serum response factor

1

1

High-throughput

0.618

High

1392906

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

1433681

SH22A
SH2 domain-containing protein 2A

2

4

High-throughput

0.594

High

1032046

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.586

High

260450

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.584

High

1110077

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.536

High

1368120

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.536

High

975938

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.515

High

167396

KLF11
Krueppel-like factor 11

1

20

High-throughput

0.515

High

856923

BAG6
Large proline-rich protein BAG6

1

6

High-throughput

0.515

High

927135

ATX3
Ataxin-3

1

1

High-throughput

0.515

High

143253

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

404419

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

474288

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

520374

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

623542

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

Small-scale

0.479

High

675674

TYY1
Transcriptional repressor protein YY1

1

10

High-throughput

0.479

High

776130

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

776250

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

887221

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.479

High

944741

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

981092

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

986723

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

995267

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

998803

H31
Histone H3.1

1

8

High-throughput

0.479

High

1017206

H33
Histone H3.3

1

8

High-throughput

0.479

High

1033227

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

1088015

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1097556

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

1133659

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1141305

BRD3
Bromodomain-containing protein 3

1

13

High-throughput

0.479

High

1364252

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1367270

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1433685

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

570598

GFAP
Glial fibrillary acidic protein

1

3

High-throughput

0.470

High

129424

MEN1
Menin

1

0

High-throughput

0.458

High

683894

MOES
Moesin

1

0

High-throughput

0.458

High

1289627

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1313427

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1338372

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1433682

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

995818

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.437

High

1142396

PDIA6
Protein disulfide-isomerase A6

3

0

High-throughput

0.347

High

1294923

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

1

0

High-throughput

0.279

Low

1382689

COQA1
Collagen alpha-1(XXVI) chain

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025