HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	7797522, 19109251, 17474147
Identification Methods	far western blotting, affinity chromatography technology, pull down, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 217
+	Hs
		557629 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337383 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		69204 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46
+	Hs
		61732 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		A6H8W8_HUMAN (2-61): 6.74e-15: 75: 36.67
+	Hs
		787985 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		412069 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		787920 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Cl
		47357 A0A8I3PJA6_CANLF (1-896): 5.87e-149: 464: 92.91		F1PHV6_CANLF (137-216): 8.63e-12: 65.7: 26.25
+	Mm
		788010 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		ITSN1_MOUSE (137-216): 1.77e-12: 67.7: 25.00
+	Hs
		1349275 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		411908 MRCKB_HUMAN (223-886): 2.4e-41: 167: 12.72		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		1078919 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		434101 MRCKB_HUMAN (223-886): 2.4e-41: 167: 12.72		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		1078828 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		433781 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		259644 LIPA2_HUMAN (210-884): 2.13e-31: 134: 11.53		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		337577 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Rn
		92844 E9PSY8_RAT (9-333): 4.64e-17: 88.3: 11.66		ITSN1_RAT (137-216): 1.01e-11: 65.7: 25.00
+	Hs
		61738 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		A6H8W8_HUMAN (2-61): 6.74e-15: 75: 36.67