HitPredict

Interactor 1: BRCC3 (P46736)
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
Gene: BRCC3

Interactor 2: BABA1 (Q9NWV8)
BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)
Gene: BABAM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.55	0.722

The method score is based on:

Property	Details
Experiments	30755420, 19615732, 19261749, 20032457, 21282113, 19261748, 26186194, 28514442, 33961781, 19261746
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006282 - regulation of DNA repair and 9 others more... GO:0006302 - double-strand break repair GO:0007095 - mitotic G2 DNA damage checkpoint signaling GO:0010212 - response to ionizing radiation GO:0044818 - mitotic G2/M transition checkpoint GO:0045739 - positive regulation of DNA repair GO:0051301 - cell division GO:0070531 - BRCA1-A complex GO:0070552 - BRISC complex GO:0140861 - DNA repair-dependent chromatin remodeling
Homologous interactions	0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024