HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30110629
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2414 Hs			1 425
+	Hs
		997692 EP300_HUMAN (1-2414): 0: 1113: 100.00		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		929419 EP300_HUMAN (1-2414): 0: 1113: 100.00		RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41
+	Hs
		903172 EP300_HUMAN (1-2414): 0: 1113: 100.00		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61
+	Hs
		999028 EP300_HUMAN (1-2414): 0: 1113: 100.00		GRWD1_HUMAN (307-404): 4.14e-14: 75.7: 23.47
+	Hs
		1017306 BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86		RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00
+	Hs
		1083336 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00
+	Hs
		929725 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41
+	Hs
		1074790 BRDT_HUMAN (1036-1159): 2.03e-33: 143: 29.84		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Hs
		631433 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Hs
		1066968 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Sp
		252179 YK82_SCHPO (990-1155): 2.19e-28: 126: 20.48		NLE1_SCHPO (2-152): 3.93e-32: 129: 10.90
+	Hs
		997694 BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		997936 CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		1074799 PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Hs
		997838 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		929460 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41
+	Hs
		903374 KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61
+	Hs
		903405 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61
+	Sc
		975959 GCN5_YEAST (1074-1156): 2.55e-12: 73.6: 38.55		RRB1_YEAST (234-423): 6.78e-13: 72.2: 12.15